Evidence map›Paper›PMID 26658119›Full record

Trial reportJournal of perinatology : official journal of the California Perinatal Association2016

Buccal administration of human colostrum: impact on the oral microbiota of premature infants.

K Sohn, K M Kalanetra, D A Mills, M A Underwood

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03393832 (Oral Care), which is not on this map. Cited by 48 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
48citing papers in PubMed, 9 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03393832 active not recruitingnot on this mapstarted 2017, after this paper: background citation

Oral Care: An Important Adjunctive Therapy to Improve Feeding Tolerance in Infants With Gastroschisis

TypeobservationalSponsorBaylor College of MedicineRan2017 to 2026Enrolled27ConditionsGastroschisis
3 · Its place in the literature

Who cites it

48 citing papers in PubMed, 9 syntheses or guidelines pooled it.

  1. Pooled it
  2. [Effect of colostrum oral immune therapy on the the clinical outcomes in very low birth weight infants: a Meta analysis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2025
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  12. Oral colostrum priming shortens hospitalization without changing the immunomicrobial milieu.Journal of perinatology : official journal of the California Perinatal Association · 2017
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  19. A Scoping Review of the Oral Microbiome in Preterm Infants.American journal of perinatology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

K SohnDivision of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA, USA.
K M KalanetraDepartment of Food Science and Technology, University of California Davis, Davis, CA, USA.
D A MillsDepartment of Food Science and Technology, University of California Davis, Davis, CA, USA.
M A UnderwoodDivision of Neonatology, Department of Pediatrics, University of California Davis, Sacramento, CA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo determine whether the administration of mother's colostrum into the buccal pouch in the first days of life alters the oral microbiota compared with control infants. STUDY

designIn this pilot study, 12 very low birth weight (VLBW) infants were randomly assigned to receive either colostrum from their mothers directly into the buccal pouch every 2 h for 46 h or standard care. We analyzed the oral microbiota at initiation and 48 and 96 h later using next-generation sequencing.

resultThe oral microbiota changed markedly over the 96 h period in all babies. Patterns of colonization differed between groups with Planococcaceae, the dominant family at 48 and 96 h in the colostrum group, and Moraxellaceae and Staphylococcaceae, the dominant families at 48 and 96 h, respectively, in the control group.

conclusionBuccal administration of mother's colostrum to VLBW infants influenced the colonization of the oral cavity with differences persisting 48 h after completion of the intervention.

Indexed as

MouthAdministration, BuccalColostrumFemaleHumansInfant, NewbornInfant, Newborn, DiseasesInfant, PrematureInfant, Very Low Birth WeightMaleMicrobiotaPilot ProjectsPregnancyRespiration, ArtificialTime-to-TreatmentTreatment Outcome

Identifiers

PMID26658119

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.