ArticleNature communications2015
Presynaptic hyperpolarization induces a fast analogue modulation of spike-evoked transmission mediated by axonal sodium channels.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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Who cites it
42 citing papers in PubMed, 75 citations in OpenAlex.
- Stabilized Ion Selectivity Corrects Activation Drift in Kalium Channelrhodopsins.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- cAMP reduces action potential amplitude and conduction velocity over long axonal distance.The Journal of physiology · 2025Article
- The Effects of Overexpressing K2p Channels in Various Tissues on Physiology and Behaviors.Insects · 2025Article
- Functional Maturation and Experience-Dependent Plasticity in Adult-Born Olfactory Bulb Dopaminergic Neurons.The European journal of neuroscience · 2025Article
- Biophysical properties of the membrane influence spike initiation dynamics and neuronal excitability: a focus on Kv1 channels in myelinated axons.Proceedings. Biological sciences · 2025Review
- Central terminals of primary afferents coordinate the spontaneous activity of dorsal horn neurons.The Journal of physiology · 2025Article
- Intrinsic and synaptic regulation of axonal excitability in dopaminergic neurons.Frontiers in cellular neuroscience · 2025Review
- Membrane potential states gate synaptic consolidation in human neocortical tissue.Nature communications · 2024Article
- Enhanced Release Probability without Changes in Synaptic Delay during Analogue-Digital Facilitation.Cells · 2024Article
- The computational power of the human brain.Frontiers in cellular neuroscience · 2023Review
- All-optical observation on activity-dependent nanoscale dynamics of myelinated axons.Neurophotonics · 2023Article
- The periodic axon membrane skeleton leads to Na nanodomains but does not impact action potentials.Biophysical journal · 2022Article
- Impact of In Utero Exposure to Antiepileptic Drugs on Neonatal Brain Function.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Time Is of the Essence: Neural Codes, Synchronies, Oscillations, Architectures.Frontiers in computational neuroscience · 2022Article
- Homeostatic regulation of axonal Kv1.1 channels accounts for both synaptic and intrinsic modifications in the hippocampal CA3 circuit.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Voltage-Gated Potassium Channels Ensure Action Potential Shape Fidelity in Distal Axons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- How inhibitory neurons increase information transmission under threshold modulation.Cell reports · 2021Article
- Calcium and Spike Timing-Dependent Plasticity.Frontiers in cellular neuroscience · 2021Review
- Fluorescence lifetime imaging reveals regulation of presynaptic CaJournal of neurochemistry · 2021Article
- Synaptic plasticity rules with physiological calcium levels.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the mammalian brain, synaptic transmission usually depends on presynaptic action potentials (APs) in an all-or-none (or digital) manner. Recent studies suggest, however, that subthreshold depolarization in the presynaptic cell facilitates spike-evoked transmission, thus creating an analogue modulation of a digital process (or analogue-digital (AD) modulation). At most synapses, this process is slow and not ideally suited for the fast dynamics of neural networks. We show here that transmission at CA3-CA3 and L5-L5 synapses can be enhanced by brief presynaptic hyperpolarization such as an inhibitory postsynaptic potential (IPSP). Using dual soma-axon patch recordings and live imaging, we find that this hyperpolarization-induced AD facilitation (h-ADF) is due to the recovery from inactivation of Nav channels controlling AP amplitude in the axon. Incorporated in a network model, h-ADF promotes both pyramidal cell synchrony and gamma oscillations. In conclusion, cortical excitatory synapses in local circuits display hyperpolarization-induced facilitation of spike-evoked synaptic transmission that promotes network synchrony.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.