ArticleScientific reports2015
The well-coordinated linkage between acidogenicity and aciduricity via insoluble glucans on the surface of Streptococcus mutans.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 82 citations in OpenAlex.
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- Prevalence of oral streptococci and glucosyltransferase genes in mother-child pairs: a cross-sectional study in Turkish families.BMC pediatrics · 2026Article
- Buprenorphine enhancesJournal of oral microbiology · 2026Article
- Fluoride varnish application and the temporal evolution of supragingival microbiota in children with differential caries risk.Journal of oral microbiology · 2026Article
- Antibacterial and anti-biofilm effects of postbiotic mediator derived fromJournal of oral microbiology · 2026Article
- Novel two-stage expansion of Streptococcus mutans biofilm supports EPS-targeted prevention strategies for early childhood caries.NPJ biofilms and microbiomes · 2025Article
- Molecular Docking and Experimental Analysis of Essential Oil-Based Preparations on Biofilm Formation on Orthodontic Archwires.International journal of molecular sciences · 2024Article
- The Effect of Bovine Trypsin on the Adhesion and pH of Dental Plaque Biofilms: An In Vitro Study.International dental journal · 2024Article
- Contemporary strategies and approaches for characterizing composition and enhancing biofilm penetration targeting bacterial extracellular polymeric substances.Journal of pharmaceutical analysis · 2024Review
- How probiotics, prebiotics, synbiotics, and postbiotics prevent dental caries: an oral microbiota perspective.NPJ biofilms and microbiomes · 2024Review
- The effect of different sweeteners on the oral microbiome: a randomized clinical exploratory pilot study.Journal of oral microbiology · 2024Article
- Anti-bacterial and anti-biofilm activities of arachidonic acid against the cariogenic bacteriumFrontiers in microbiology · 2024Article
- Dental Caries: Unveiling the State-of-the-art Insights and Crafting Hypotheses for Oral Health.Current pharmaceutical design · 2024Review
- ComprehensiveFrontiers in microbiology · 2024Article
- Oral Microbiota: A New Insight into Cancer Progression, Diagnosis and Treatment.Phenomics (Cham, Switzerland) · 2023Review
- In Situ Raman Analysis of Biofilm Exopolysaccharides Formed inInternational journal of molecular sciences · 2023Article
- mltG gene deletion mitigated virulence potential of Streptococcus mutans: An in-vitro, ex-situ and in-vivo study.AMB Express · 2023Article
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Streptococcus mutans is considered the principal cariogenic bacterium for dental caries. Despite the recognition of their importance for cariogenesis, the possible coordination among S. mutans' main virulence factors, including glucan production, acidogenicity and aciduricity, has been less well studied. In the present study, using S. mutans strains with surface-displayed pH-sensitive pHluorin, we revealed sucrose availability- and Gtf functionality-dependent proton accumulation on S. mutans surface. Consistent with this, using a pH-sensitive dye, we demonstrated that both in vivo cell-produced and in vitro enzymatically synthesized insoluble glucans displayed proton-concentrating ability. Global transcriptomics revealed proton accumulation triggers the up-regulation of genes encoding functions involved in acid tolerance response in a glucan-dependent manner. Our data suggested that this proton enrichment around S. mutans could pre-condition the bacterium for acid-stress. Consistent with this hypothesis, we found S. mutans strains defective in glucan production were more acid sensitive. Our study revealed for the first time that insoluble glucans is likely an essential factor linking acidogenicity with aciduricity. The coordination of these key virulence factors could provide new insights on how S. mutans may have become a major cariogenic pathogen.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.