ArticleScientific reports2015
Epigenomic Reprogramming of Adult Cardiomyocyte-Derived Cardiac Progenitor Cells.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Article
- Single-cell transcriptomes in the heart: when every epigenome counts.Cardiovascular research · 2023Review
- Proliferation and Maturation: Janus and the Art of Cardiac Tissue Engineering.Circulation research · 2023Review
- Extracellular vesicles in cardiac repair and regeneration: Beyond stem-cell-based approaches.Frontiers in cell and developmental biology · 2022Review
- Asiaticoside alleviates cardiomyocyte apoptosis and oxidative stress in myocardial ischemia/reperfusion injury via activating theAnnals of translational medicine · 2022Article
- Dedifferentiated human umbilical cord mesenchymal stem cell reprogramming of endogenous hSDF-1α expression participates in neural restoration in hypoxic-ischemic brain damage rats.Genes & diseases · 2021Article
- Hunting down the dominating subclone of cancer stem cells as a potential new therapeutic target in multiple myeloma: An artificial intelligence perspective.World journal of stem cells · 2020Review
- Review
- Single-cell imaging and transcriptomic analyses of endogenous cardiomyocyte dedifferentiation and cycling.Cell discovery · 2019Article
- Insights from molecular signature of in vivo cardiac c-Kit(+) cells following cardiac injury and β-catenin inhibition.Journal of molecular and cellular cardiology · 2018Article
- Epigenomes in Cardiovascular Disease.Circulation research · 2018Review
- Mechanisms of Cardiac Repair and Regeneration.Circulation research · 2018Review
- High content analysis identifies unique morphological features of reprogrammed cardiomyocytes.Scientific reports · 2018Article
- Single Cell Gene Expression to Understand the Dynamic Architecture of the Heart.Frontiers in cardiovascular medicine · 2018Review
- Molecular basis of functional myogenic specification of Bona Fide multipotent adult cardiac stem cells.Cell cycle (Georgetown, Tex.) · 2018Review
- The roles of non-coding RNAs in cardiac regenerative medicine.Non-coding RNA research · 2017Review
- Single-cell transcriptome and epigenomic reprogramming of cardiomyocyte-derived cardiac progenitor cells.Scientific data · 2016Article
- Bmi1 (+) cardiac progenitor cells contribute to myocardial repair following acute injury.Stem cell research & therapy · 2016Article
- Dynamic visualization of DNA methylation in cell cycle genes during iPSC cardiac differentiation.EpigenomicsArticle
Corrections and comments
- Commented on by
- Erratum issued
Authors and funding
6 authors.
Funding
Abstract
It has been believed that mammalian adult cardiomyocytes (ACMs) are terminally-differentiated and are unable to proliferate. Recently, using a bi-transgenic ACM fate mapping mouse model and an in vitro culture system, we demonstrated that adult mouse cardiomyocytes were able to dedifferentiate into cardiac progenitor-like cells (CPCs). However, little is known about the molecular basis of their intrinsic cellular plasticity. Here we integrate single-cell transcriptome and whole-genome DNA methylation analyses to unravel the molecular mechanisms underlying the dedifferentiation and cell cycle reentry of mouse ACMs. Compared to parental cardiomyocytes, dedifferentiated mouse cardiomyocyte-derived CPCs (mCPCs) display epigenomic reprogramming with many differentially-methylated regions, both hypermethylated and hypomethylated, across the entire genome. Correlated well with the methylome, our transcriptomic data showed that the genes encoding cardiac structure and function proteins are remarkably down-regulated in mCPCs, while those for cell cycle, proliferation, and stemness are significantly up-regulated. In addition, implantation of mCPCs into infarcted mouse myocardium improves cardiac function with augmented left ventricular ejection fraction. Our study demonstrates that the cellular plasticity of mammalian cardiomyocytes is the result of a well-orchestrated epigenomic reprogramming and a subsequent global transcriptomic alteration.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.