ArticleDevelopment (Cambridge, England)2016
Neurogenic gene regulatory pathways in the sea urchin embryo.
Article in Development (Cambridge, England), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- From Genes to Gonads: Molecular Control Points of Reproduction in the Sea Urchin as a Framework for Aquaculture.International journal of molecular sciences · 2026Review
- Non-visual photoreceptive brain specification in sea urchin larvae.Nature communications · 2025Article
- An Integrated Canonical and Non-Canonical Wnt Signaling Network Controls Early Anterior-Posterior Axis Formation in Sea Urchin Embryos.Journal of developmental biology · 2025Review
- Article
- NvPrdm14d-expressing neural progenitor cells contribute to non-ectodermal neurogenesis in Nematostella vectensis.Nature communications · 2023Article
- Echinoderm radial glia in adult cell renewal, indeterminate growth, and regeneration.Frontiers in neural circuits · 2023Review
- Thyroid hormone membrane receptor binding and transcriptional regulation in the sea urchinFrontiers in endocrinology · 2023Article
- microRNA-124 regulates Notch and NeuroD1 to mediate transition states of neuronal development.Developmental neurobiology · 2023Article
- Homologous gene regulatory networks control development of apical organs and brains in Bilateria.Science advances · 2022Article
- Development of a larval nervous system in the sea urchin.Current topics in developmental biology · 2022Review
- Yamanaka Factors in the Budding TunicateFrontiers in cell and developmental biology · 2022Article
- Single-cell RNA sequencing of theeLife · 2021Article
- Developmental origin of peripheral ciliary band neurons in the sea urchin embryo.Developmental biology · 2020Article
- A biphasic role of non-canonical Wnt16 signaling during early anterior-posterior patterning and morphogenesis of the sea urchin embryo.Development (Cambridge, England) · 2019Article
- Evolution of nitric oxide regulation of gut function.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Reference assembly and gene expression analysis of Apostichopus japonicus larval development.Scientific reports · 2019Article
- Spatial and temporal patterns of gene expression during neurogenesis in the sea urchinEvoDevo · 2019Article
- Neurogenesis in the sea urchin embryo is initiated uniquely in three domains.Development (Cambridge, England) · 2018Article
- Embryonic expression patterns and phylogenetic analysis of panarthropod sox genes: insight into nervous system development, segmentation and gonadogenesis.BMC evolutionary biology · 2018Article
- Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo.Developmental biology · 2018Article
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3 authors.
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Abstract
During embryogenesis the sea urchin early pluteus larva differentiates 40-50 neurons marked by expression of the pan-neural marker synaptotagmin B (SynB) that are distributed along the ciliary band, in the apical plate and pharyngeal endoderm, and 4-6 serotonergic neurons that are confined to the apical plate. Development of all neurons has been shown to depend on the function of Six3. Using a combination of molecular screens and tests of gene function by morpholino-mediated knockdown, we identified SoxC and Brn1/2/4, which function sequentially in the neurogenic regulatory pathway and are also required for the differentiation of all neurons. Misexpression of Brn1/2/4 at low dose caused an increase in the number of serotonin-expressing cells and at higher dose converted most of the embryo to a neurogenic epithelial sphere expressing the Hnf6 ciliary band marker. A third factor, Z167, was shown to work downstream of the Six3 and SoxC core factors and to define a branch specific for the differentiation of serotonergic neurons. These results provide a framework for building a gene regulatory network for neurogenesis in the sea urchin embryo.
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