Evidence map›Paper›PMID 26657504›Full record

ArticleOncotarget2016

Regulatory T cells may participate in Helicobacter pylori persistence in gastric MALT lymphoma: lessons from an animal model.

Amandine Marine Laur, Pauline Floch, Lucie Chambonnier, Lucie Benejat, Victoria Korolik, Alban Giese, Pierre Dubus, Francis Mégraud, Antonio Bandeira, Philippe Lehours

Open access · diamondAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
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  3. Article
  4. Review
  5. Review
  6. Article
  7. The Role of Gastric Mucosal Immunity in Gastric Diseases.Journal of immunology research · 2020
    Review
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Amandine Marine LaurUniversity Bordeaux, Bacteriology Laboratory, Bordeaux, France.
Pauline FlochUniversity Bordeaux, Bacteriology Laboratory, Bordeaux, France.
Lucie ChambonnierUniversity Bordeaux, Bacteriology Laboratory, Bordeaux, France.
Lucie BenejatUniversity Bordeaux, Bacteriology Laboratory, Bordeaux, France.
Victoria KorolikInstitute for Glycomics, Griffith University, Nathan QLD, Australia.
Alban GieseUniversity Bordeaux, EA 2406, Bordeaux, France.
Pierre DubusUniversity Bordeaux, EA 2406, Bordeaux, France.
Francis MégraudUniversity Bordeaux, Bacteriology Laboratory, Bordeaux, France.
Antonio BandeiraUnit for Biology of Lymphocyte Populations, Immunology Department, Institut Pasteur and CIMI, Unity of Treg Biology and Therapy, University of Pierre & Marie Curie, Paris, France.
Philippe LehoursUniversity Bordeaux, Bacteriology Laboratory, Bordeaux, France.
Université de Bordeaux · FRInserm · FRBordeaux Population Health · FRGriffith University · AUInstitut Pasteur · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been postulated that the emergence of autoimmune gastritis in neonatal thymectomised (d3Tx) BALB/c mice may be a consequence of post-surgery deficit in Tregs. In this study, previously obtained samples from d3Tx mice were used in order to determine whether thymectomy creates a deficit in this T cell subset thereby allowing the emergence of autoimmune phenomena as a prerequisite for GML. The splenic Treg reserve and the local recruitment of these cells in the gastric mucosa were investigated using complementary molecular and immunohistochemistry approaches. Higher Foxp3/CD3 ratios were found in the spleen of non-infected d3Tx mice compared to non-thymectomised (NTx) controls. These results indicate a relative enrichment of Tregs following thymectomy in adult mice. The absence of Treg depletion in d3Tx mice is in line with the absence of auto-immune gastritis in non-infected d3Tx mice. Higher levels of T cell and Treg infiltration were also found in the stomach of GML-developing d3Tx mice versus NTx mice. Surprisingly, inflammatory scores inversely correlated with the bacterial inoculum. The presence of a small Treg containing compartment among gastric biopsies of GML developing d3Tx mice may play a role in perseverance of a minimal bacterial numbers thereby maintaining an antigen-dependent stimulation and proliferation.

Indexed as

Disease Models, AnimalAnimalsGastric MucosaHelicobacter InfectionsHelicobacter pyloriImmunoenzyme TechniquesLymphoma, B-Cell, Marginal ZoneLymphoma, Non-HodgkinMiceReal-Time Polymerase Chain ReactionReverse Transcriptase Polymerase Chain ReactionRNA, MessengerStomach NeoplasmsT-Lymphocytes, RegulatoryRNA, Messengeranimal modelHelicobacter pyloriMALT lymphomaregulatory T cell

Identifiers

PMID26657504
PMCPMC4823114
OpenAlexW2220402185

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.