Evidence map›Paper›PMID 26657475›Full record

ArticleEuropean heart journal. Cardiovascular Imaging2016

Association between the vasa vasorum and the atherosclerotic changes in cardiac allograft vasculopathy: volumetric analysis.

Kyoung-Ha Park, Taek-Geun Kwon, Yasushi Matsuzawa, Tao Sun, Zhi Liu, Ryan J Lennon, Lilach O Lerman, Sudhir S Kushwaha, Amir Lerman

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in European heart journal. Cardiovascular Imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Review
  3. The role of optical coherence tomography and other intravascular imaging modalities in cardiac allograft vasculopathy.Postepy w kardiologii interwencyjnej = Advances in interventional cardiology · 2020
    Review
  4. Article
  5. Peripheral vascular atherosclerosis in a novel PCSK9 gain-of-function mutant Ossabaw miniature pig model.Translational research : the journal of laboratory and clinical medicine · 2018
    Article
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Kyoung-Ha ParkDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA Division of Cardiovascular Disease, Hallym University Medical Center, Anyang, Korea.
Taek-Geun KwonDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Yasushi MatsuzawaDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Tao SunDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Zhi LiuDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Ryan J LennonDivision of Biomedical Statistics and Informatics, Mayo Clinic, Rochester, MN, USA.
Lilach O LermanDivision of Nephrology and Hypertension, Mayo Clinic, Rochester, MN, USA.
Sudhir S KushwahaDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA.
Amir LermanDivision of Cardiovascular Diseases, Department of Internal Medicine, Mayo Clinic, 200 First Street SW, Rochester, MN, USA lerman.amir@mayo.edu.

Funding

Lp-PLA2 and Coronary Atherosclerosis in HumansR01HL092954 · NHLBI · MAYO CLINIC ROCHESTER · PI LERMAN, AMIR · 2009 to 2013
$2.1M
NHLBI NIH HHS HL-92954NHLBI NIH HHS R01 HL092954NIA NIH HHS AG-3170
6 · The paper itself

Abstract

aimsThe current study was designed to test that vasa vasorum (VV) plays a role in the progression of cardiac allograft vasculopathy (CAV) in patients with heart transplantation (HTX). METHODS AND

resultsIntravascular ultrasound (IVUS) and optical coherence tomography (OCT) were performed in the left anterior descending artery in 19 segments of 19 HTX patients (median 2.1 years from HTX). Each segment is composed of both the continuous lesions: (i) CAV area: intimal thickness >0.5 mm with 5 mm length and (ii) VV area: intimal thickness ≤0.5 mm with 5 mm length. The per cent VV volume (VV volume/vessel volume × 100, %VV) was evaluated in the VV area with OCT (in CAV area VV cannot be assessed because of limited penetration power of OCT). A year later, the association between the baseline %VV and the change in per cent plaque volume (plaque volume/vessel volume × 100, %PV) was evaluated with IVUS. To a normal distribution, Δ%PV (follow-up %PV-initial %PV) was undergone square root transformation. The correlations between the %VV at baseline study and square root-Δ%PV were significant both in the CAV area and in the VV area (r = 0.787, P < 0.001 and r = 0.701, P < 0.001, respectively). In multivariable analysis, only the %VV was significantly correlated with square root-Δ%PV in both areas.

conclusionThe current study demonstrated a significant association between the VV volume and the progression of plaque volume in both the CAV area and the VV area. Thus, VV may be a potential predictor and possible therapeutic target to attenuate CAV.

Indexed as

Heart TransplantationAgedAllograftsCoronary Artery DiseaseDisease ProgressionFemaleFollow-Up StudiesHumansMaleMiddle AgedRisk FactorsTomography, Optical CoherenceUltrasonography, InterventionalVasa Vasorumcardiac allograft vasculopathyheart transplantationvasa vasorum

Identifiers

PMID26657475
PMCPMC4750508

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.