ArticleScientific reports2015
Resistance Mechanisms and Molecular Docking Studies of Four Novel QoI Fungicides in Peronophythora litchii.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 45 citations in OpenAlex.
- Baseline Sensitivity of Botryosphaeria spp. Isolated from Apples to Pyraclostrobin in Korea.The plant pathology journal · 2025Article
- Exploring putative enteric methanogenesis inhibitors using molecular simulations and a graph neural network.bioRxiv : the preprint server for biology · 2024Article
- Deciphering fungicide resistance in Phytophthora: mechanisms, prevalence, and sustainable management approaches.World journal of microbiology & biotechnology · 2024Review
- Transcriptome Analysis Reveals the Involvement of Mitophagy and Peroxisome in the Resistance to QoIs inMicroorganisms · 2023Article
- Article
- Progress Report: Antimicrobial Drug Discovery in the Resistance Era.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Characterization of the Molecular Mechanisms of Resistance against DMI Fungicides inJournal of fungi (Basel, Switzerland) · 2021Article
- Strobilurin biosynthesis in Basidiomycete fungi.Nature communications · 2018Article
- Computer-Aided Drug Discovery in Plant Pathology.The plant pathology journal · 2017Review
Corrections and comments
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Authors and funding
11 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peronophythora litchii is the causal agent of litchi downy blight. Enestroburin, SYP-1620, SYP-2815 and ZJ0712 are four novel QoI fungicides developed by China. Eight mutants of P. litchii resistant to these QoI fungicides and azoxystrobin (as a known QoI fungicide) were obtained in our preliminary work. In this study, the full length of the cytochrome b gene in P. litchii, which has a full length of 382 amino acids, was cloned from both sensitive isolates and resistant mutants, and single-site mutations G142A, G142S, Y131C, or F128S were found in resistant mutants. Molecular docking was used to predict how the mutations alter the binding of the five QoI fungicides to the Qo-binding pockets. The results have increased our understanding of QoI fungicide-resistance mechanisms and may help in the development of more potent inhibitors against plant diseases in the fields.
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Registered trials
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