Evidence map›Paper›PMID 26657132›Full record

ArticlePloS one2015

Myocardial Ischemic Subject's Thymus Fat: A Novel Source of Multipotent Stromal Cells.

Wilfredo Oliva-Olivera, Leticia Coín-Aragüez, Julián Salas, Said Lhamyani, Adriana-Mariel Gentile, Esteban Sarria García, Abdelkrim Hmadcha, Hatem Zayed, Antonio Vega-Rioja, Francisco J Tinahones and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 7 institutions in 2 countries.

Wilfredo Oliva-OliveraCIBER Pathophysiology of obesity and nutrition CB06/03, Carlos III Health Institute, Malaga, 29010, Spain, Laboratory of Biomedical Research, Virgen de la Victoria Clinical University Hospital, Málaga, 29010, Spain.
Leticia Coín-AragüezCIBER Pathophysiology of obesity and nutrition CB06/03, Carlos III Health Institute, Malaga, 29010, Spain, Laboratory of Biomedical Research, Virgen de la Victoria Clinical University Hospital, Málaga, 29010, Spain.
Julián SalasCardiovascular Surgery Department, University Hospital Carlos Haya, Málaga, Spain.
Said LhamyaniResearch Laboratory, Science School, Málaga University, Campus Teatinos s/n- 29071, Málaga, Spain.
Adriana-Mariel GentileResearch Laboratory, Science School, Málaga University, Campus Teatinos s/n- 29071, Málaga, Spain.
Esteban Sarria GarcíaCardiovascular Surgery Department, University Hospital Carlos Haya, Málaga, Spain.
Abdelkrim HmadchaAndalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Department of Stem Cells, Sevilla, Spain, Centro de Investigación Biomédica en Red-Diabetes y Enfermedades Metabólicas (CIBERDEM), Instituto de Salud Carlos III, Madrid, Spain.
Hatem ZayedBiomedical Sciences Program, Health Sciences Department, College of Arts and Sciences, Qatar University, P.O. Box: 2713, Doha, Qatar.
Antonio Vega-RiojaServicio Regional de Inmunología y Alergia, Hospital Universitario Virgen Macarena, Sevilla, Spain.
Francisco J TinahonesCIBER Pathophysiology of obesity and nutrition CB06/03, Carlos III Health Institute, Malaga, 29010, Spain, Laboratory of Biomedical Research, Virgen de la Victoria Clinical University Hospital, Málaga, 29010, Spain.
Rajaa El BekayCIBER Pathophysiology of obesity and nutrition CB06/03, Carlos III Health Institute, Malaga, 29010, Spain, Laboratory of Biomedical Research, Virgen de la Victoria Clinical University Hospital, Málaga, 29010, Spain.
Hospital Clínico Universitario Virgen de la Victoria · ESHospital Doctor José Molina Orosa · ESInstituto de Salud Carlos III · ESUniversidad de Málaga · ESCentro de Investigación Biomédica en Red · ESHospital Universitario Virgen Macarena · ESQatar University · QA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveAdipose Tissue Stromal Cells (ASCs) have important clinical applications in the regenerative medicine, cell replacement and gene therapies. Subcutaneous Adipose Tissue (SAT) is the most common source of these cells. The adult human thymus degenerates into adipose tissue (TAT). However, it has never been studied before as a source of stem cells. MATERIAL AND

methodsWe performed a comparative characterization of TAT-ASCs and SAT-ASCs from myocardial ischemic subjects (n = 32) according to the age of the subjects.

resultsTAT-ASCs and SAT-ASCs showed similar features regarding their adherence, morphology and in their capacity to form CFU-F. Moreover, they have the capacity to differentiate into osteocyte and adipocyte lineages; and they present a surface marker profile corresponding with stem cells derived from AT; CD73+CD90+CD105+CD14-CD19-CD45-HLA-DR. Interestingly, and in opposition to SAT-ASCs, TAT-ASCs have CD14+CD34+CD133+CD45- cells. Moreover, TAT-ASCs from elderly subjects showed higher adipogenic and osteogenic capacities compared to middle aged subjects, indicating that, rather than impairing; aging seems to increase adipogenic and osteogenic capacities of TAT-ASCs.

conclusionsThis study describes the human TAT as a source of mesenchymal stem cells, which may have an enormous potential for regenerative medicine.

Indexed as

AdipogenesisAdipose TissueAgedCell DifferentiationCell ProliferationColony-Forming Units AssayFatty Acid-Binding ProteinsFlow CytometryGene ExpressionHumansImmunophenotypingMesenchymal Stem CellsMiddle AgedMyocardial IschemiaOsteogenesisRegenerative MedicineFABP4 protein, humanFatty Acid-Binding ProteinsSREBF1 protein, humanSterol Regulatory Element Binding Protein 1

Identifiers

PMID26657132
PMCPMC4675557
OpenAlexW2190596501

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.