ArticleHearing research2016
The middle ear muscle reflex in the diagnosis of cochlear neuropathy.
Article in Hearing research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
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Who cites it
62 citing papers in PubMed, 105 citations in OpenAlex.
- Differentiating Middle Ear and Medial Olivocochlear Effects on Transient-Evoked Otoacoustic Emissions.Journal of the Association for Research in Otolaryngology : JARO · 2017Trial
- Cochlear aging after synaptopathic noise: age-noise interactions in hair cell loss and axonal degeneration.Hearing research · 2026Article
- Broadband Noise Acoustic Stapedial Reflex Thresholds as a Marker of Cochlear and Neural Integrity in Individuals with Normal Audiograms.Audiology research · 2026Article
- Rapid Characterization of Middle-Ear Muscle Reflexes Using Swept Elicitors.Journal of the Association for Research in Otolaryngology : JARO · 2026Article
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Cochlear histopathology in macaques after noise-induced temporary threshold shifts.Hearing research · 2026Article
- Consequences and Mechanisms of Noise-Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- Deciphering Auditory Hyperexcitability in Otogl Mutant Mice Unravels an Auditory Neuropathy Mechanism.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Cochlear Synaptopathy in Full-Term Neonates: A Case-Control Study of NICU Hospitalization Impact.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- A Systematic Review: State of the Science on Diagnostics of Hidden Hearing Loss.Diagnostics (Basel, Switzerland) · 2025Review
- The relationship and interdependence of auditory thresholds, proposed behavioural measures of hidden hearing loss, and physiological measures of auditory function.International journal of audiology · 2025Article
- A Consolidated Understanding of the Contribution of Redox Dysregulation in the Development of Hearing Impairment.Antioxidants (Basel, Switzerland) · 2024Review
- Sound elicits stereotyped facial movements that provide a sensitive index of hearing abilities in mice.Current biology : CB · 2024Article
- Noise-induced synaptic loss and its post-exposure recovery in CBA/CaJ vs. C57BL/6J mice.Hearing research · 2024Article
- Evidence of cochlear neural degeneration in normal-hearing subjects with tinnitus.Scientific reports · 2023Article
- Abnormal outer hair cell efferent innervation in Hoxb1-dependent sensorineural hearing loss.PLoS genetics · 2023Article
- Wideband Acoustic Reflex Measurement.Seminars in hearing · 2023Review
- The middle ear muscle reflex: Current and future role in assessing noise-induced cochlear damage.The Journal of the Acoustical Society of America · 2023Article
- Noise-induced hearing disorders: Clinical and investigational tools.The Journal of the Acoustical Society of America · 2023Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cochlear neuropathy, i.e. the loss of auditory nerve fibers (ANFs) without loss of hair cells, may cause hearing deficits without affecting threshold sensitivity, particularly if the subset of ANFs with high thresholds and low spontaneous rates (SRs) is preferentially lost, as appears to be the case in both aging and noise-damaged cochleas. Because low-SR fibers may also be important drivers of the medial olivocochlear reflex (MOCR) and middle-ear muscle reflex (MEMR), these reflexes might be sensitive metrics of cochlear neuropathy. To test this hypothesis, we measured reflex strength and reflex threshold in mice with noise-induced neuropathy, as documented by confocal analysis of immunostained cochlear whole-mounts. To assay the MOCR, we measured contra-noise modulation of ipsilateral distortion-product otoacoustic emissions (DPOAEs) before and after the administration of curare to block the MEMR or curare + strychnine to also block the MOCR. The modulation of DPOAEs was 1) dominated by the MEMR in anesthetized mice, with a smaller contribution from the MOCR, and 2) significantly attenuated in neuropathic mice, but only when the MEMR was intact. We then measured MEMR growth functions by monitoring contra-noise induced changes in the wideband reflectance of chirps presented to the ipsilateral ear. We found 1) that the changes in wideband reflectance were mediated by the MEMR alone, and 2) that MEMR threshold was elevated and its maximum amplitude was attenuated in neuropathic mice. These data suggest that the MEMR may be valuable in the early detection of cochlear neuropathy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.