ArticleBlood purification2015
Uremic Solutes Produced by Colon Microbes.
Article in Blood purification, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed.
- Probiotic treatment induces changes in intestinal microbiota but does not alter SCFA levels in peritoneal dialysis patients-a randomized, placebo-controlled trial.Scientific reports · 2024Trial
- Gut-kidney axis: Dysbiosis and renal disease.World journal of nephrology · 2026Review
- Integrative metagenomics and metabolomics reveal age-associated gut microbiota and metabolite alterations in a hamster model of COVID-19.Gut microbes · 2025Article
- Protein-bound uremic toxins as therapeutic targets for cardiovascular, kidney, and metabolic disorders.Frontiers in endocrinology · 2025Review
- Interaction between mitochondria and microbiota modulating cellular metabolism in inflammatory bowel disease.Journal of molecular medicine (Berlin, Germany) · 2023Review
- Alterations of gut microbes and their correlation with clinical features in middle and end-stages chronic kidney disease.Frontiers in cellular and infection microbiology · 2023Article
- Gut Microbiota as a Source of Uremic Toxins.International journal of molecular sciences · 2022Article
- Gut Microbiome-Derived Uremic Toxin Levels in Hemodialysis Patients on Different Phosphate Binder Therapies.Blood purification · 2022Article
- Microbial metabolism of L-tyrosine protects against allergic airway inflammation.Nature immunology · 2021Article
- Article
- The Importance of Metabolism for Immune Homeostasis in Allergic Diseases.Frontiers in immunology · 2021Review
- Aberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents.Gut · 2020Observational
- Temporal and tissue-specific activation of aryl hydrocarbon receptor in discrete mouse models of kidney disease.Kidney international · 2020Article
- Chronic kidney disease in cats alters response of the plasma metabolome and fecal microbiome to dietary fiber.PloS one · 2020Article
- Comparison of circulating metabolite concentrations in dogs and cats when allowed to freely choose macronutrient intake.Biology open · 2018Article
- Poisoning with Soman, an Organophosphorus Nerve Agent, Alters Fecal Bacterial Biota and Urine Metabolites: a Case for Novel Signatures for Asymptomatic Nerve Agent Exposure.Applied and environmental microbiology · 2018Article
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Authors and funding
3 authors.
Funding
Abstract
backgroundColon microbes produce a large number of organic compounds that are foreign to mammalian cell metabolism. SUMMARY: Some of the compounds made by microbes are absorbed in the colon and then normally excreted by the kidneys. Accumulation of these compounds in the plasma as uremic solutes may contribute to illness in patients whose kidneys have failed. Mass spectrometry is expanding our knowledge of the chemical identity of the colon-derived uremic solutes, and DNA sequencing technologies are providing new knowledge of the microbes and metabolic pathways by which they are made. Because they are made in an isolated compartment by microbes, their production may prove simpler to suppress than the production of other uremic solutes. KEY MESSAGES: To the extent that they are toxic, suppressing their production could improve the health of renal failure patients without the need for more intensive or prolonged dialysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.