ArticleMagnetic resonance imaging2016
Investigation of NAA and NAAG dynamics underlying visual stimulation using MEGA-PRESS in a functional MRS experiment.
Article in Magnetic resonance imaging, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 34 citations in OpenAlex.
- 1H MR spectroscopy of the motor cortex immediately following transcranial direct current stimulation at 7 Tesla.PloS one · 2018Trial
- A systematic approach to MR spectroscopy of the brain: Indications, protocol, metabolites, and spectral analysis in neurologic diseases.The neuroradiology journal · 2026Review
- Thalamic metabolite changes after subthalamic nucleus deep brain stimulation in Parkinson's disease: an exploratory magnetic resonance spectroscopy study.Frontiers in neurology · 2025Article
- Metabolic alterations in patients with essential tremor before and after deep brain stimulation: keys to understanding tremor using magnetic resonance spectroscopy.Frontiers in neurology · 2025Article
- Cellular and molecular mechanisms of aspartoacylase and its role in Canavan disease.Cell & bioscience · 2024Review
- Concentrations of glutamate andFrontiers in molecular neuroscience · 2024Article
- Neurometabolic timecourse of healthy aging.NeuroImage · 2022Article
- Metabolite differences in the medial prefrontal cortex in schizophrenia patients with and without persistent auditory verbal hallucinations: aTranslational psychiatry · 2022Article
- 3T MEGA-PRESS study of N-acetyl aspartyl glutamate and N-acetyl aspartate in activated visual cortex.Magma (New York, N.Y.) · 2021Article
- The potential ofPsychopharmacology · 2021Review
- The neurobiology of wellness:NeuroImage · 2021Article
- Neurochemical correlates of scene processing in the precuneus/posterior cingulate cortex: A multimodal fMRI andHuman brain mapping · 2019Article
- Medial Frontal Lobe Neurochemistry in Autism Spectrum Disorder is Marked by Reduced N-Acetylaspartate and Unchanged Gamma-Aminobutyric Acid and Glutamate + Glutamine Levels.Journal of autism and developmental disorders · 2018Article
- Working Memory Modulates Glutamate Levels in the Dorsolateral Prefrontal Cortex duringFrontiers in psychiatry · 2018Article
- Elevated Choline-Containing Compound Levels in Rapid Cycling Bipolar Disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2017Article
- EditedMagnetic resonance in medicine · 2017Review
- Dual-volume excitation and parallel reconstruction for J-difference-edited MR spectroscopy.Magnetic resonance in medicine · 2017Article
- Stimulation-induced transient changes in neuronal activity, blood flow and N-acetylaspartate content in rat prefrontal cortex: a chemogenetic fMRS-BOLD study.NMR in biomedicine · 2016Article
- HERMES: Hadamard encoding and reconstruction of MEGA-edited spectroscopy.Magnetic resonance in medicine · 2016Article
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
Abstract
N-acetyl-aspartate (NAA) is responsible for the majority of the most prominent peak in (1)H-MR spectra, and has been used as diagnostic marker for several pathologies. However, ~10% of this peak can be attributed to N-acetyl-aspartyl-glutamate (NAAG), a neuropeptide whose release may be triggered by intense neuronal activation. Separate measurement of NAA and NAAG using MRS is difficult due to large superposition of their spectra. Specifically, in functional MRS (fMRS) experiments, most work has evaluated the sum NAA+NAAG, which does not appear to change during experiments. The aim of this work was to design and perform an fMRS experiment using visual stimulation and a spectral editing sequence, MEGA-PRESS, to further evaluate the individual dynamics of NAA and NAAG during brain activation. The functional paradigm used consisted of three blocks, starting with a rest (baseline) block of 320 s, followed by a stimulus block (640 s) and a rest block (640 s). Twenty healthy subjects participated in this study. On average, subjects followed a pattern of NAA decrease and NAAG increase during stimulation, with a tendency to return to basal levels at the end of the paradigm, with a peak NAA decrease of -(21±19)% and a peak NAAG increase of (64±62)% (Wilcoxon test, p<0.05). These results may relate to: 1) the only known NAAG synthesis pathway is from NAA and glutamate; 2) a relationship between NAAG and the BOLD response.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.