Evidence map›Paper›PMID 26656888›Full record

ReviewPathogens and disease2016

Inhibiting bacterial toxins by channel blockage.

Sergey M Bezrukov, Ekaterina M Nestorovich

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Pathogens and disease, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.3field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Sergey M BezrukovProgram in Physical Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA.
Ekaterina M NestorovichDepartment of Biology, The Catholic University of America, Washington, DC 20064, USA nestorovich@cua.edu.
Catholic University of America · USNational Institutes of Health · US

Funding

Biophysics of Large Membrane ChannelsZIAHD000072 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BEZRUKOV, SERGEY M · 2009 to 2025
$22.8M
OBSTRUCTING TOXIN'S PATHWAYS: UNIVERSAL INHIBITORS OF BINARY BACTERIAL TOXINSR15AI099897 · NIAID · CATHOLIC UNIVERSITY OF AMERICA · PI NESTOROVICH, EKATERINA · 2014 to 2014
$423k
Intramural NIH HHSNIAID NIH HHS 1R15AI099897-01A1NIAID NIH HHS R15 AI099897
6 · The paper itself

Abstract

Emergent rational drug design techniques explore individual properties of target biomolecules, small and macromolecule drug candidates, and the physical forces governing their interactions. In this minireview, we focus on the single-molecule biophysical studies of channel-forming bacterial toxins that suggest new approaches for their inhibition. We discuss several examples of blockage of bacterial pore-forming and AB-type toxins by the tailor-made compounds. In the concluding remarks, the most effective rationally designed pore-blocking antitoxins are compared with the small-molecule inhibitors of ion-selective channels of neurophysiology.

Indexed as

Drug DesignAntitoxinsBacterial ToxinsDrug DiscoveryInhibitory Concentration 50PorinsStructure-Activity RelationshipAntitoxinsBacterial ToxinsPorinschannel-blocking antitoxinsmultivalent interactionsphysical forces of efficient blockagerational drug designsingle molecule/protein interactionstructure-based drug discovery

Identifiers

PMID26656888
PMCPMC4830228
OpenAlexW2289088457

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.