ReviewSchizophrenia bulletin2016
Brain Biomarkers of Vulnerability and Progression to Psychosis.
Review in Schizophrenia bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it.
- Predictors of transition in patients with clinical high risk for psychosis: an umbrella review.Translational psychiatry · 2023Pooled it
- Does Hippocampal Volume Predict Transition to Psychosis in a High-Risk Group? A Meta-Analysis.Frontiers in psychiatry · 2020Pooled it
- Oxidative Stress and Inflammation in First-Episode Psychosis: A Systematic Review and Meta-analysis.Schizophrenia bulletin · 2019Pooled it
- Prefrontal Cortex Dysfunction as a Precipitating Factor for Schizophrenia and Depression.Journal of neurochemistry · 2026Review
- Correlation of Neuroimaging Biomarkers and Pharmacogenetic Profiles in Optimizing Personalized Therapy in Children and Adolescents with Psychotic Disorders.Neurology international · 2025Article
- Relations of Lifetime Perceived Stress and Basal Cortisol With Hippocampal Volume Among Healthy Adolescents and Those at Clinical High Risk for Psychosis: A Structural Equation Modeling Approach.Biological psychiatry · 2024Article
- Multimodal fusion of brain signals for robust prediction of psychosis transition.Schizophrenia (Heidelberg, Germany) · 2024Article
- Toll-Like Receptor mRNA Levels in Schizophrenia: Association With Complement Factors and Cingulate Gyrus Cortical Thinning.Schizophrenia bulletin · 2024Article
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- Auditory Steady-State Responses in Schizophrenia: An Updated Meta-Analysis.Brain sciences · 2023Review
- Accelerated cortical thinning precedes and predicts conversion to psychosis: The NAPLS3 longitudinal study of youth at clinical high-risk.Molecular psychiatry · 2023Article
- Blood Viscosity and Inflammation in First-Episode and Acute Exacerbations of Schizophrenia: A Case-Control Study with Healthy Controls.Noro psikiyatri arsivi · 2023Article
- Cortical and Subcortical Structural Morphometric Profiles in Individuals with Nonaffective and Affective Early Illness Psychosis.Schizophrenia bulletin open · 2022Article
- Cognitive subtypes in recent onset psychosis: distinct neurobiological fingerprints?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
- Cellular and extracellular white matter alterations indicate conversion to psychosis among individuals at clinical high-risk for psychosis.The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry · 2021Article
- Neural Correlates of Mentalizing in Individuals With Clinical High Risk for Schizophrenia: ALE Meta-Analysis.Frontiers in psychiatry · 2021Review
- Cortical Gyrification, Psychotic-Like Experiences, and Cognitive Performance in Nonclinical Subjects.Schizophrenia bulletin · 2020Article
- Cortical Complexity in People at Ultra-High-Risk for Psychosis Moderated by Childhood Trauma.Frontiers in psychiatry · 2020Article
- Abnormal relationships between local and global brain measures in subjects at clinical high risk for psychosis: a pilot study.Brain imaging and behavior · 2018Article
- Blood-Based Protein Changes in Childhood Are Associated With Increased Risk for Later Psychotic Disorder: Evidence From a Nested Case-Control Study of the ALSPAC Longitudinal Birth Cohort.Schizophrenia bulletin · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Identifying predictors and elucidating the fundamental mechanisms underlying onset of psychosis are critical for the development of targeted preemptive interventions. This article presents a selective review of findings on risk prediction algorithms and potential mechanisms of onset in youth at clinical high-risk for psychosis, focusing principally on recent findings of the North American Prodrome Longitudinal Study (NAPLS). Multivariate models incorporating risk factors from clinical, demographic, neurocognitive, and psychosocial assessments achieve high levels of predictive accuracy when applied to individuals who meet criteria for a prodromal risk syndrome. An individualized risk calculator is available to scale the risk for newly ascertained cases, which could aid in clinical decision making. At risk individuals who convert to psychosis show elevated levels of proinflammatory cytokines, as well as disrupted resting state thalamo-cortical functional connectivity at baseline, compared with those who do not. Further, converters show a steeper rate of gray matter reduction, most prominent in prefrontal cortex, that in turn is predicted by higher levels of inflammatory markers at baseline. Microglia, resident immune cells in the brain, have recently been discovered to influence synaptic plasticity in health and impair plasticity in disease. Processes that modulate microglial activation may represent convergent mechanisms that influence brain dysconnectivity and risk for onset of psychosis and thus may be targetable in developing and testing preventive interventions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.