Evidence map›Paper›PMID 26656859›Full record

ArticleJournal of the American Heart Association2015

Repolarization Alternans and Ventricular Arrhythmia in a Repaired Tetralogy of Fallot Animal Model.

Shuenn-Nan Chiu, Chia-Ti Tsai, Lian-Yu Lin, Shu-Chien Huang, Yih-Sharng Chen, Jou-Kou Wang, Mei-Hwan Wu, Ling-Ping Lai, Jiunn-Lee Lin

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.5field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Review
  2. Importance of Cx43 for Right Ventricular Function.International journal of molecular sciences · 2021
    Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Shuenn-Nan ChiuDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (S.N.C., J.K.W., M.H.W.).
Chia-Ti TsaiDepartment of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (C.T.T., L.Y.L., L.P.L., J.L.L.).
Lian-Yu LinDepartment of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (C.T.T., L.Y.L., L.P.L., J.L.L.).
Shu-Chien HuangDepartment of Surgery, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (S.C.H., Y.S.C.).
Yih-Sharng ChenDepartment of Surgery, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (S.C.H., Y.S.C.).
Jou-Kou WangDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (S.N.C., J.K.W., M.H.W.).
Mei-Hwan WuDepartment of Pediatrics, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (S.N.C., J.K.W., M.H.W.).
Ling-Ping LaiDepartment of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (C.T.T., L.Y.L., L.P.L., J.L.L.).
Jiunn-Lee LinDepartment of Medicine, National Taiwan University Hospital, National Taiwan University, Taipei, Taiwan (C.T.T., L.Y.L., L.P.L., J.L.L.).
National Taiwan University Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundVentricular arrhythmia is an important cause of late death in patients with repaired tetralogy of Fallot (rTOF). By using an rTOF canine model, we investigated the role of repolarization alternans and its electrophysiological mechanisms. METHODS AND

resultsSix dogs received right ventricular outflow tract (RVOT) transannular patch, pulmonary valve destruction, and right bundle branch ablation to simulate rTOF. After 1 year, we performed high-resolution dual-voltage and calcium optical mapping to record action potentials and calcium transients on the excised right ventricular outflow tract wedges. Another 6 dogs without operation served as control. The rTOF group was more susceptible to action potential duration alternans (APD-ALT) and spatially discordant APD-ALT than control (threshold for APD-ALT: 516±36 vs 343±36 ms; P=0.017; threshold for discordant APD-ALT: 387±30 vs 310±14 ms; P=0.046). We detected 2 episodes of ventricular tachycardia in the rTOF group, but none in the control. Expressions of Kv4.3 and KChIP2 decreased in the rTOF group. Expression of connexin 43 also decreased in the rTOF group with a corresponding decrease of conduction velocity and might contribute to spatially discordant APD-ALT. We also found distinct electrophysiological features of the RVOT, including biphasic relationship between magnitude of APD-ALT and pacing cycle length, uncoupling of APD-ALT, and calcium transients alternans, and shortened APD, but unchanged, APD restitution in rTOF.

conclusionsWe demonstrated novel electrophysiological properties of the RVOT. In an rTOF model, the RVOT exhibits increased susceptibility to temporal and spatially discordant APD-ALT, which was not totally dependent on calcium transient alternans.

Indexed as

AnimalsArrhythmias, CardiacConnexin 43ConnexinsDisease Models, AnimalDogsElectrocardiographyGap Junction alpha-5 ProteinHeartHeart Conduction SystemIon ChannelsMyocardiumReal-Time Polymerase Chain ReactionTetralogy of FallotConnexin 43ConnexinsGap Junction alpha-5 ProteinIon Channelsaction potentialsconnexin 43ion channelstachyarrhythmiastetralogy of Fallot

Identifiers

PMID26656859
PMCPMC4845286
OpenAlexW2193168632

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.