Evidence map›Paper›PMID 26656858›Full record

ArticleJournal of the American Heart Association2015

Acute Kidney Injury Risk Prediction in Patients Undergoing Coronary Angiography in a National Veterans Health Administration Cohort With External Validation.

Jeremiah R Brown, Todd A MacKenzie, Thomas M Maddox, James Fly, Thomas T Tsai, Mary E Plomondon, Christopher D Nielson, Edward D Siew, Frederic S Resnic, Clifton R Baker and 2 more

Open access · goldAbstract read
In one paragraph

Article in Journal of the American Heart Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 4 pooled it
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 4 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Trial
  6. Contrast-Induced Nephropathy.Annals of vascular diseases · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Article
  11. Article
  12. Review
  13. Racial Differences in AKI Incidence Following Percutaneous Coronary Intervention.Journal of the American Society of Nephrology : JASN · 2021
    Article
  14. Article
  15. Coronary artery bypass graft markers: history, usage, and effects.General thoracic and cardiovascular surgery · 2020
    Review
  16. Article
  17. Article
  18. Article
  19. Review
  20. Calibration drift in regression and machine learning models for acute kidney injury.Journal of the American Medical Informatics Association : JAMIA · 2017
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 10 institutions in 1 country.

Jeremiah R BrownWhite River Junction VA, Research & Development Service, White River Junction, VT (J.R.B., T.A.M.K.) The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Lebanon, NH (J.R.B., T.A.M.K.) Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH (J.R.B.) Department of Community and Family Medicine, Geisel School of Medicine, Lebanon, NH (J.R.B., T.A.M.K.).
Todd A MacKenzieWhite River Junction VA, Research & Development Service, White River Junction, VT (J.R.B., T.A.M.K.) The Dartmouth Institute for Health Policy and Clinical Practice, Geisel School of Medicine, Lebanon, NH (J.R.B., T.A.M.K.) Department of Community and Family Medicine, Geisel School of Medicine, Lebanon, NH (J.R.B., T.A.M.K.).
Thomas M MaddoxMedical Service, VA Eastern Colorado Health Care System, Denver, CO (T.M.M., T.T.T.) Division of Cardiology, University of Colorado School of Medicine, Denver, CO (T.M.M., J.S.R.) Clinical Assessment Reporting and Tracking Program, VA Central Office, Denver, CO (T.M.M., M.E.P., J.S.R.).
James FlyGeriatrics Research Education & Clinical Center (GRECC), Tennessee Valley Healthcare System (TVHS), Veteran's Health Administration, Nashville, TN (J.F., E.D.S., M.E.M.) Division of General Internal Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (J.F., M.E.M.).
Thomas T TsaiMedical Service, VA Eastern Colorado Health Care System, Denver, CO (T.M.M., T.T.T.) Kaiser Permanente of Colorado, Denver, CO (T.T.T.).
Mary E PlomondonClinical Assessment Reporting and Tracking Program, VA Central Office, Denver, CO (T.M.M., M.E.P., J.S.R.) Division of Health Systems, Management, and Policy, University of Colorado School of Public Health, Denver, CO (M.E.P.).
Christopher D NielsonOffice of Analytics and Business Intelligence, VA Central Office, Veterans Health Administration, Seattle, WA (C.D.N., C.R.B.) Division of Pulmonary Medicine and Critical Care, University of Nevada, Reno, NV (C.D.N.).
Edward D SiewGeriatrics Research Education & Clinical Center (GRECC), Tennessee Valley Healthcare System (TVHS), Veteran's Health Administration, Nashville, TN (J.F., E.D.S., M.E.M.) Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (E.D.S.).
Frederic S ResnicDepartment of Cardiology, Lahey Clinic, Burlington, MA (F.S.R.).
Clifton R BakerOffice of Analytics and Business Intelligence, VA Central Office, Veterans Health Administration, Seattle, WA (C.D.N., C.R.B.).
John S RumsfeldDivision of Cardiology, University of Colorado School of Medicine, Denver, CO (T.M.M., J.S.R.) Clinical Assessment Reporting and Tracking Program, VA Central Office, Denver, CO (T.M.M., M.E.P., J.S.R.).
Michael E MathenyGeriatrics Research Education & Clinical Center (GRECC), Tennessee Valley Healthcare System (TVHS), Veteran's Health Administration, Nashville, TN (J.F., E.D.S., M.E.M.) Division of General Internal Medicine, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN (J.F., M.E.M.) Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, TN (M.E.M.) Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN (M.E.M.).
Geriatric Research Education and Clinical Center · USUniversity of Colorado Denver · USColorado School of Public Health · USDartmouth Institute for Health Policy and Clinical Practice · USLahey Hospital and Medical Center · USUniversity of Nevada, Reno · USVA Eastern Colorado Health Care System · USVanderbilt University · USVeterans Health Administration · USWhite River Junction VA Medical Center · US

Funding

Nutrition and Metabolism in Dialysis PatientsK24DK062849 · NIDDK · VANDERBILT UNIVERSITY · PI IKIZLER, TALAT ALP · 2003 to 2012
$1.6M
Diagnostic and Prognostic Relevance of Acute Kidney Injury Biomarkers in the ICUK23DK088964 · NIDDK · VANDERBILT UNIVERSITY · PI SIEW, EDWARD D · 2011 to 2013
$518k
National Surveillance of Acute Kidney Injury Following Cardiac CatheterizationI01HX000853 · VA · VETERANS HEALTH ADMINISTRATION · PI MATHENY, MICHAEL E. · 2013 to 2013
–
AHRQ HHS K01 HS018443HSRD VA I01 HX000853HSRD VA I01 HX001280NIDDK NIH HHS K23 DK088964NIDDK NIH HHS K24 DK062849
6 · The paper itself

Abstract

backgroundAcute kidney injury (AKI) occurs frequently after cardiac catheterization and percutaneous coronary intervention. Although a clinical risk model exists for percutaneous coronary intervention, no models exist for both procedures, nor do existing models account for risk factors prior to the index admission. We aimed to develop such a model for use in prospective automated surveillance programs in the Veterans Health Administration. METHODS AND

resultsWe collected data on all patients undergoing cardiac catheterization or percutaneous coronary intervention in the Veterans Health Administration from January 01, 2009 to September 30, 2013, excluding patients with chronic dialysis, end-stage renal disease, renal transplant, and missing pre- and postprocedural creatinine measurement. We used 4 AKI definitions in model development and included risk factors from up to 1 year prior to the procedure and at presentation. We developed our prediction models for postprocedural AKI using the least absolute shrinkage and selection operator (LASSO) and internally validated using bootstrapping. We developed models using 115 633 angiogram procedures and externally validated using 27 905 procedures from a New England cohort. Models had cross-validated C-statistics of 0.74 (95% CI: 0.74-0.75) for AKI, 0.83 (95% CI: 0.82-0.84) for AKIN2, 0.74 (95% CI: 0.74-0.75) for contrast-induced nephropathy, and 0.89 (95% CI: 0.87-0.90) for dialysis.

conclusionsWe developed a robust, externally validated clinical prediction model for AKI following cardiac catheterization or percutaneous coronary intervention to automatically identify high-risk patients before and immediately after a procedure in the Veterans Health Administration. Work is ongoing to incorporate these models into routine clinical practice.

Indexed as

Decision Support TechniquesAcute Kidney InjuryAgedCardiac CatheterizationCoronary AngiographyFemaleHumansLogistic ModelsMalePercutaneous Coronary InterventionReproducibility of ResultsRisk FactorsUnited StatesUnited States Department of Veterans Affairsangiographyangioplastycatheterizationcontrast mediakidney

Identifiers

PMID26656858
PMCPMC4845295
OpenAlexW2194673183

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.