ArticleJournal of acquired immune deficiency syndromes (1999)2016
Anal Cancer Screening in Men Who Have Sex With Men in the Multicenter AIDS Cohort Study.
Article in Journal of acquired immune deficiency syndromes (1999), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 40 citations in OpenAlex.
- Two Web-Based and Theory-Based Interventions With and Without Brief Motivational Interviewing in the Promotion of Human Papillomavirus Vaccination Among Chinese Men Who Have Sex With Men: Randomized Controlled Trial.Journal of medical Internet research · 2021Trial
- Comparison of nylon-flocked swab and Dacron swab cytology for anal HSIL detection in transgender women and gay, bisexual, and other men who have sex with men.Cancer cytopathology · 2019Trial
- Behavioral intention to perform risk compensation behaviors after receiving HPV vaccination among men who have sex with men in China.Human vaccines & immunotherapeutics · 2019Trial
- Self-reported anal cancer screening experiences in MSM: recency, follow-up, and methodological insights.Frontiers in oncology · 2026Article
- Uptake and service preferences of human papillomavirus vaccination in men who have sex with men.Human vaccines & immunotherapeutics · 2025Article
- Article
- High Grade Anal Dysplasia in People Living with HIV: A Review of the Anal Cancer/HSIL Outcomes Research (ANCHOR) Trial. Implications for Screening and Treatment Strategies to Minimize Anal Cancer in a Very High-risk Population.International journal of cancer care and delivery · 2023Article
- Follow-Up to High-Resolution Anoscopy After Abnormal Anal Cytology in People Living with HIV.AIDS patient care and STDs · 2022Article
- Would Chinese Men Who Have Sex With Men Take Up Human Papillomavirus (HPV) Screening as an Alternative Prevention Strategy to HPV Vaccination?Frontiers in medicine · 2022Article
- Article
- Facilitators and Barriers to Take Up Clinician-Collected and Self-Collected HPV Tests among Chinese Men Who Have Sex with Men.Viruses · 2021Article
- Management of anal intraepithelial neoplasia and anal squamous cell carcinoma at a tertiary referral centre with a dedicated infectious diseases unit: an 18-year review.International journal of colorectal disease · 2020Article
- Prevalence of Anal Squamous Intraepithelial Lesions in HIV-1-Infected Young Men Who Have Sex With Men and Transwomen.Journal of lower genital tract disease · 2018Article
- Factors Associated with High-Grade Anal Intraepithelial Lesion in HIV-Positive Men in a Southern U.S. City.AIDS research and human retroviruses · 2018Article
- Patterns of repeated anal cytology results among HIV-positive and HIV-negative men who have sex with men.Papillomavirus research (Amsterdam, Netherlands) · 2018Article
- Risk factors for anal high-grade squamous intraepithelial lesions in HIV-positive MSM: is targeted screening possible?AIDS (London, England) · 2017Article
- Racial Disparity in Gastrointestinal Cancer Risk.Gastroenterology · 2017Review
- Human Papillomavirus (HPV) 16 E6 seropositivity is elevated in subjects with oral HPV16 infection.Cancer epidemiology · 2016Article
Corrections and comments
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Authors and funding
12 authors at 1 institution in 1 country.
Funding
Abstract
objectiveTo evaluate the prevalence of anal cytology (ACyt) abnormalities among HIV-infected and HIV-uninfected men who have sex with men (MSM).
designMulticenter cohort study of 723 HIV-infected and 788 HIV-uninfected MSM with ACyt, with a second ACyt collected 2 years later. A referral for high-resolution anoscopy was suggested for abnormal ACyt.
methodsACyt samples were collected using a polyester swab and liquid cytology media and read in a central laboratory.
resultsPrevalence of any abnormal ACyt was 25% in HIV-uninfected MSM and increased to 38%, 41%, and 47% among HIV-infected MSM with current CD4 T-cell counts ≥500, 350-499, and <350 cells/mm (P < 0.001), respectively. Anal HPV16 DNA was also more common in HIV-infected than HIV-uninfected MSM (25% versus 16%, P < 0.001). Abnormal baseline ACyt together with prevalent HPV16 DNA detection was present in only 7% of HIV-uninfected MSM compared to 18% of HIV-infected MSM with current CD4 < 350, P < 0.001. Among HIV-infected men, 56% of the men with atypical squamous cells of undetermined significance or low-grade squamous intraepithelial lesions ASCs-US/LSILs and 81% of men with atypical squamous cells cannot exclude high-grade (ASC-H/)/high-grade squamous intraepithelial lesions (HSIL) had lower grade ACyt findings 18-30 months later ("regressed"). However, 19% of untreated HIV-infected men with ASC-H/HSIL cytology maintained that same grade of cytology in their second test approximately 2 years later, and 15% with ASC-US/LSIL "progressed" to ASC-H/HSIL. Abnormal ACyt had high sensitivity (96%) but low specificity (17%) for biopsy-proven HSIL.
conclusionsPrevalence of abnormal ACyt remains elevated in HIV-infected men during the current antiretroviral therapy era.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.