ArticleScientific reports2015
Duration of Untreated Psychosis and Brain Function during Verbal Fluency Testing in First-Episode Schizophrenia: A Near-Infrared Spectroscopy Study.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- The two-back task leads to activity in the left dorsolateral prefrontal cortex in schizophrenia patients with predominant negative symptoms: a fNIRS study and its implication for tDCS.Experimental brain research · 2024Trial
- Mind the delay: duration of untreated psychosis is associated with short-term outcomes in first-episode schizophrenia.Frontiers in psychiatry · 2026Article
- The fNIRS evaluation of frontal and temporal lobe cortical activation in Chinese first-episode medication-naïve and recurrent depression during a verbal fluency task.Frontiers in psychiatry · 2023Article
- The neurobiology of duration of untreated psychosis: a comprehensive review.Molecular psychiatry · 2023Review
- Differentiating people with schizophrenia from healthy controls in a developing Country: An evaluation of portable functional near infrared spectroscopy (fNIRS) as an adjunct diagnostic tool.Frontiers in psychiatry · 2023Article
- Atypical frontotemporal cortical activity in first-episode adolescent-onset schizophrenia during verbal fluency task: A functional near-infrared spectroscopy study.Frontiers in psychiatry · 2023Article
- Functional near-infrared spectroscopy in developmental psychiatry: a review of attention deficit hyperactivity disorder.European archives of psychiatry and clinical neuroscience · 2022Review
- Similarities and Differences in Brain Activation Between Patients With Schizophrenia and Obsessive-Compulsive Disorder: A Near-Infrared Spectroscopy Study.Frontiers in psychiatry · 2022Article
- Reduced temporal activation during a verbal fluency test in clinical high risk of psychosis: a functional near-infrared spectroscopy-based study.General psychiatry · 2022Article
- Surface area in the insula was associated with 28-month functional outcome in first-episode psychosis.NPJ schizophrenia · 2021Article
- Personalization of Repetitive Transcranial Magnetic Stimulation for the Treatment of Major Depressive Disorder According to the Existing Psychiatric Comorbidity.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021Article
- Article
- Abnormal Cortical Activation Patterns Among Chinese-Speaking Schizophrenia Patients During Category and Letter Verbal Fluency Tasks Revealed by Multi-Channel Functional Near-Infrared Spectroscopy.Frontiers in psychiatry · 2021Article
- Deep Neural Network to Differentiate Brain Activity Between Patients With First-Episode Schizophrenia and Healthy Individuals: A Multi-Channel Near Infrared Spectroscopy Study.Frontiers in psychiatry · 2021Article
- Validating a functional near-infrared spectroscopy diagnostic paradigm for Major Depressive Disorder.Scientific reports · 2020Article
- Risk of manic switch with antidepressants use in patients with bipolar disorder in a Nigerian neuropsychiatric hospital.The South African journal of psychiatry : SAJP : the journal of the Society of Psychiatrists of South Africa · 2018Article
- Application of Functional Near-Infrared Spectroscopy to the Study of Brain Function in Humans and Animal Models.Molecules and cells · 2017Review
- Perceived Occupational Stress is associated with Decreased Cortical Activity of the Prefrontal Cortex: A Multichannel Near-infrared Spectroscopy Study.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A longer duration of untreated psychosis (DUP) has been associated with poor clinical outcomes in patients with schizophrenia (SZ); however, it remains unclear whether this is due to neurotoxic effects of psychosis. The purpose of this study was to use near-infrared spectroscopy (NIRS) to investigate the influence of DUP on brain function using two verbal fluency tests (VFTs) in patients with first-episode SZ (FES). A total of 28 FES patients and 29 healthy controls (HC) underwent NIRS during VFTs. Group comparisons of cortical activity were made using two-tailed t-tests and the false discovery rate method. We then examined the associations between DUP and hemodynamic changes in each channel to identify any effects of DUP on brain cortical activity. During the letter VFT, the HC group exhibited significantly greater cortical activations over bilateral frontotemporal regions compared to FES patients. However, this distinction was not observed while performing a category version of the VFT. In addition, no associations between DUP and brain cortical activity were observed in the FES group during either VFT. In conclusion, we did not find an association between DUP and frontotemporal cortical activities. This might be because neurodevelopmental disturbances result in neurocognitive deficits long before psychotic symptoms onset.
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