ArticleNature communications2015
Left-right asymmetric cell intercalation drives directional collective cell movement in epithelial morphogenesis.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.
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Who cites it
51 citing papers in PubMed.
- Human Endothelial Membrane as a Structural Prototype: A Comparative Analysis withInternational journal of molecular sciences · 2026Article
- Heat-mediated manipulation of gene expression by IR-LEGO in the developing genitalia in Drosophila.G3 (Bethesda, Md.) · 2026Article
- Enamel decussation pattern originates from directional sliding of ameloblasts.International journal of oral science · 2026Article
- Contractile forces direct the chiral swirling of minimal cell collectives.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Supracellular Mechanics and Counter-Rotational Bilateral Flows Orchestrate Posterior Morphogenesis.bioRxiv : the preprint server for biology · 2025Article
- Migrating mesoderm cells self-organize into a dynamic meshwork structure during chick gastrulation.eLife · 2025Article
- Epithelial cell chirality emerges through the dynamic concentric pattern of actomyosin cytoskeleton.eLife · 2025Article
- Vertex models capturing subcellular scales in epithelial tissues.PLoS computational biology · 2025Review
- Tissue shear as a cue for aligning planar polarity in the developing Drosophila wing.Nature communications · 2025Article
- Chromophore-Assisted Light Inactivation for Protein Degradation and Its Application in Biomedicine.Bioengineering (Basel, Switzerland) · 2024Review
- Biomechanical Modeling of Cell Chirality and Symmetry Breaking of Biological Systems.Mechanobiology in medicine · 2024Article
- Cell jamming regulates epithelial chiral morphogenesis.Journal of biomechanics · 2023Article
- A cell membrane model that reproduces cortical flow-driven cell migration and collective movement.Frontiers in cell and developmental biology · 2023Article
- Interacting with tumor cells weakens the intrinsic clockwise chirality of endothelial cells.APL bioengineering · 2022Article
- The emergence of spontaneous coordinated epithelial rotation on cylindrical curved surfaces.Science advances · 2022Article
- Mechanical coupling of supracellular stress amplification and tissue fluidization during exit from quiescence.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Inhibition of negative feedback for persistent epithelial cell-cell junction contraction by p21-activated kinase 3.Nature communications · 2022Article
- Dynamic self-organization of migrating cells under constraints by spatial confinement and epithelial integrity.The European physical journal. E, Soft matter · 2022Article
- Sculpting tissues by phase transitions.Nature communications · 2022Review
- Cell Chirality as a Novel Measure for Cytotoxicity.Advanced biology · 2022Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Morphogenetic epithelial movement occurs during embryogenesis and drives complex tissue formation. However, how epithelial cells coordinate their unidirectional movement while maintaining epithelial integrity is unclear. Here we propose a novel mechanism for collective epithelial cell movement based on Drosophila genitalia rotation, in which epithelial tissue rotates clockwise around the genitalia. We found that this cell movement occurs autonomously and requires myosin II. The moving cells exhibit repeated left-right-biased junction remodelling, while maintaining adhesion with their neighbours, in association with a polarized myosin II distribution. Reducing myosinID, known to cause counter-clockwise epithelial-tissue movement, reverses the myosin II distribution. Numerical simulations revealed that a left-right asymmetry in cell intercalation is sufficient to induce unidirectional cellular movement. The cellular movement direction is also associated with planar cell-shape chirality. These findings support a model in which left-right asymmetric cell intercalation within an epithelial sheet drives collective cellular movement in the same direction.
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