Trial reportBMJ open2015
Alcohol consumption and mortality in patients with mild Alzheimer's disease: a prospective cohort study.
Trial report in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Alcohol-Induced Dysregulation of Hydrogen Sulfide Signaling in Alzheimer's Disease-International journal of molecular sciences · 2026Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the association between alcohol consumption and mortality in patients recently diagnosed with mild Alzheimer's disease (AD).
designA post hoc analysis study based on a clinical trial population.
settingThe data reported were collected as part of the Danish Alzheimer's Intervention Study (DAISY), a longitudinal multicentre randomised controlled study on the efficacy of psychosocial intervention in patients with mild AD across five county districts in Denmark.
participants321 patients with mild AD (Mini-Mental State Examination ≥ 20) were included. Data regarding current daily alcohol consumption were obtained from the patient's primary caregivers at inclusion. MAIN OUTCOME: All-cause mortality retrieved from The Danish Civil Registration System over a period of 36 months after baseline.
resultsInformation about alcohol consumption was obtained from all 321 study participants: 8% were abstinent, 71% only had alcohol occasionally (1 or <1 unit/day), 17% had 2-3 units/day and 4% had more than 3 units/day. An analysis adjusted for a range of potential confounders demonstrated a reduced mortality for patients with moderate alcohol consumption (2-3 units/day): HR 0.23 (95% CI (0.08 to 0.69)) compared with patients who had 1 or <1 unit/day. Mortality was not significantly different in abstinent patients or in patients with an alcohol consumption of more than 3 units/day, compared with patients drinking 1 or <1 unit/day.
conclusionsIn this cohort of patients with mild AD, moderate alcohol consumption (2-3 units/day) was associated with a significantly lower mortality over a period of 36 months. Further studies are needed in this area. These may especially focus on the association between alcohol consumption and cognitive decline in patients with AD.
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