ReviewGenes and immunity
Maternal immunity and pregnancy outcome: focus on preconception and autophagy.
Review in Genes and immunity. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- SARS-CoV-2 infection reduces the number of spermatogonial stem cells and dysregulates the transcriptional landscape of the human testis.Research square · 2026Article
- Regulatory T-Cells During Pregnancy Relate to Women's Own Childhood History of Microbial Exposure.American journal of human biology : the official journal of the Human Biology Council · 2025Article
- Semen Microbiome, Male Infertility, and Reproductive Health.International journal of molecular sciences · 2025Review
- Differences in autophagy marker levels at birth in preterm vs. term infants.Pediatric research · 2024Article
- Contribution of the seminal microbiome to paternal programming.Biology of reproduction · 2024Review
- Development of Gut Microbiota in the First 1000 Days after Birth and Potential Interventions.Nutrients · 2023Review
- Pregnancy preparation: redistribution of CCR7-positive cells in the rat uterus.Reproduction (Cambridge, England) · 2022Article
- Microorganisms in the reproductive system and probiotic's regulatory effects on reproductive health.Computational and structural biotechnology journal · 2022Review
- Article
- Microbiota and Human Reproduction: The Case of Male Infertility.High-throughput · 2020Review
- The seminal microbiome in health and disease.Nature reviews. Urology · 2019Review
- Article
- Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term.Genes and immunity · 2019Article
- Transcriptomic changes in the pre-implantation uterus highlight histotrophic nutrition of the developing marsupial embryo.Scientific reports · 2018Article
- Influence of Pregnancy History on the Vaginal Microbiome of Pregnant Women in their First Trimester.Scientific reports · 2017Article
- Hot topic: 16S rRNA gene sequencing reveals the microbiome of the virgin and pregnant bovine uterus.Journal of dairy science · 2017Article
- Increased incidence of ectopic pregnancy after in vitro fertilization in women with decreased ovarian reserve.Oncotarget · 2017Article
- Is cancer a severe delayed hypersensitivity reaction and histamine a blueprint?Clinical and translational medicine · 2016Article
- The influence of oxidative stress and autophagy cross regulation on pregnancy outcome.Cell stress & chaperones · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Modulation of the maternal immune system before conception has a major role in determining subsequent pregnancy outcome. However, this has been a neglected area of investigation. There is a correlation between the length of time a woman is exposed to semen from her male partner and the development of regulatory T cells that limit a maternal antifetal immune response. Similarly, the composition of the vaginal microbiota influences the capacity of microorganisms to bypass the cervical barrier and colonize the uterus before pregnancy. The extent that this preconception colonization influences pre- and post-implantation gestational events depends on the types of microbes present, the genetic make-up of the mother and environmental influences on the magnitude and direction of her immune responses. Prepregnancy uterine and placental colonization with commensal bacteria may be beneficial to the fetus and newborn by generating tolerance to organisms that enhance postnatal well-being. Efforts to prevent or stop the progression of premature myometrial contractions have been limited because of an incomplete understanding of the mechanism(s) that trigger this occurrence. Based on recent studies of autophagy during gestation and parturition, inhibition of autophagy in myometrial cells may be the critical factor leading to a sequence of events culminating in induction of myometrial contractions either prematurely or at term.
Indexed as
Identifiers
26656449What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.