Observational studyMedicine2015
Gender and Age Impact on the Association Between Thyroid-Stimulating Hormone and Serum Lipids.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 61 citations in OpenAlex.
- Targeting Cell Senescence and Senolytics: Novel Interventions for Age-Related Endocrine Dysfunction.Endocrine reviews · 2024Review
- Normative range of various serum hormonal parameters among Indian women of reproductive age: ICMR-PCOS task force study outcome.The Lancet regional health. Southeast Asia · 2023Article
- Prevalence and clinical correlates of psychotic symptoms in first-episode untreated female chinese patients with major depressive disorder.BMC psychiatry · 2023Article
- The Relationship of Circulating Proprotein Convertase Subtilisin/Kexin Type 9 With TSH and Lipid Profile in Newly Diagnosed Patients With Subclinical and Overt Hypothyroidism.Clinical medicine insights. Endocrinology and diabetes · 2022Article
- Gender impact on the correlations between Graves' hyperthyroidism and hyperuricemia in Chinese.Irish journal of medical science · 2019Article
- The relationship between red blood cell distribution width and metabolic syndrome in elderly Chinese: a cross-sectional study.Lipids in health and disease · 2019Article
- Gender- and Age-Specific Differences in the Association of Hyperuricemia and Hypertension: A Cross-Sectional Study.International journal of endocrinology · 2019Article
- Serum bilirubin is negatively associated with white blood cell count.Clinics (Sao Paulo, Brazil) · 2019Article
- Gender-Specific Differences on the Association of Hypertension with Subclinical Thyroid Dysfunction.International journal of endocrinology · 2019Article
- No associations exists between red blood cell distribution width and serum uric acid in both sexes.Medicine · 2018Article
- Relationship between mean platelet volume and metabolic syndrome in Chinese patients.Scientific reports · 2018Article
- The association between total bilirubin and serum triglyceride in both sexes in Chinese.Lipids in health and disease · 2018Article
- Infectious mononucleosis and hepatic function.Experimental and therapeutic medicine · 2018Article
- The Relationship between Subclinical Thyroid Disease and Cardiovascular Disease Risk Score in Koreans.Journal of Korean medical science · 2017Article
- The associations between leukocyte, erythrocyte or platelet, and metabolic syndrome in different genders of Chinese.Medicine · 2016Article
- No associations exist between mean platelet volume or platelet distribution width and thyroid function in Chinese.Medicine · 2016Observational
- Correlation between Subclinical Hypothyroidism and Metabolic Syndrome: A Retrospective Study.Saudi journal of medicine & medical sciencesArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
21 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The relationship between thyroid-stimulating hormone (TSH) and hyperlipidemia is still a topic of debate. We aimed to explore the impact of gender and age on the association between serum TSH and lipid profile in a large cohort of Chinese.This cross-sectional study enrolled 13,915 participants (8565 male, 5350 female), who self-reported as healthy without any known previous diseases. Clinical data including anthropometric measurements, thyroid function, and other serum parameters were collected. The associations between TSH and hyperlipidemia of males and females were analyzed separately after dividing TSH and age into subgroups. Odds ratio for hyperlipidemia was calculated by binary logistic regression models.Young males had significantly higher prevalence of hypercholesterolemia, hypertriglyceridemia, and high serum low-density lipoprotein-cholesterol than females, yet after menopause, females had higher prevalence than males. TSH was positively associated with hyperlipidemia independent of thyroid hormones. Males showed more reduced risks of hyperlipidemia in low TSH concentrations, while females demonstrated more enhanced risks of hyperlipidemia in high TSH concentrations. For instance, if TSH was lower than 0.3 μIU/mL, the risks of developing hypercholesterolemia and hypertriglyceridemia in males were only 0.198 (P < 0.01) and 0.425 (P < 0.05) of the reference TSH risks (between 2.0 and 3.0 μIU/mL), while in females the risks were 0.553 (P < 0.05) and 0.642 (P > 0.05), respectively. If TSH was higher than 4.0 μIU/mL, women displayed significantly higher risks of developing hypertriglyceridemia than the reference TSH risks (P < 0.05), yet, men did not demonstrate such significances.Our results showed thyroid hormone independent positive associations between serum TSH and lipids, which were substantially influenced by gender and age. Males demonstrated more protective effects of low TSH against hyperlipidemia, while females showed more detrimental effects of high TSH on hyperlipidemia.
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