Observational studyMedicine2015
Granulomas as the Most Useful Histopathological Feature in Distinguishing between Crohn's Disease and Intestinal Tuberculosis in Endoscopic Biopsy Specimens.
Observational study in Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.
- Histological approach and differentiation of Crohn's disease and gastrointestinal tuberculosis: Recommendations from the joint IAPM-ISG-CCFI Working Group.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Guideline
- Probable Isolated Rectal Tuberculosis Presenting as Mild Chronic Proctitis in an Immunocompetent Adolescent: A Diagnostic Pitfall and Mini-Review of the Literature.ACG case reports journal · 2026Article
- A diagnostic dilemma: abdominal tuberculosis mimicking suspected Crohn's disease or latent tuberculosis activated by biologic therapy.Clinical journal of gastroenterology · 2026Article
- The Overlap Between Crohn's Disease and Intestinal Tuberculosis: A Never-Ending Story.Medicina (Kaunas, Lithuania) · 2026Review
- Review
- Significance of Epidemiological Background in Preventing the Misdiagnosis of Intestinal Tuberculosis as Crohn's Disease.Internal medicine (Tokyo, Japan) · 2024Article
- Gastrointestinal tuberculosis: Diagnostic approaches for this uncommon pathology.World journal of clinical cases · 2024Article
- Deep learning model to differentiate Crohn's disease from intestinal tuberculosis using histopathological whole slide images from intestinal specimens.Virchows Archiv : an international journal of pathology · 2024Article
- Intestinal tuberculosis with small bowel stricture and hemorrhage as the predominant manifestation: Three case reports.World journal of gastrointestinal surgery · 2024Article
- Detection Rates of Non-Cavitary Epithelioid Cell Granuloma by Gastrointestinal Biopsy in Patients with Treatment-Naïve Crohn's Disease.Inflammatory intestinal diseases · 2023Article
- Differentiating gastrointestinal tuberculosis and Crohn's disease- a comprehensive review.BMC gastroenterology · 2023Review
- Diagnostic utility of CT enterography in the evaluation of ileocecal mucosal lesions of uncertain diagnosis on ileocolonoscopy.Polish journal of radiology · 2023Article
- Article
- Article
- Systematic reporting of computed tomography enterography/enteroclysis as an aid to reduce diagnostic dilemma when differentiating between intestinal tuberculosis and Crohn's disease: A prospective study at a tertiary care hospital.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- A Comprehensive Review of Infectious Granulomatous Diseases of the Gastrointestinal Tract.Gastroenterology research and practice · 2021Review
- Microscopic features of small bowel mucosa of patients with Crohn's disease.BMC gastroenterology · 2019Article
- A case of gastrointestinal tuberculosis with unusual manifestations of carcinomatosis.Clinical case reports · 2019Article
- Ten Cases of Intestinal Tuberculosis Which Were Initially Misdiagnosed as Inflammatory Bowel Disease.Internal medicine (Tokyo, Japan) · 2019Article
- Differentiating Crohn's disease from intestinal tuberculosis.World journal of gastroenterology · 2019Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The incidence of Crohn's disease (CD) is increasing in Chinese populations in whom intestinal tuberculosis (ITB) is prevalent.This study aimed to identify differential diagnostic microscopic and endoscopic characteristics of CD from those of ITB.Patients with CD (N = 52) and patients with ITB (N = 16) diagnosed between 2010 and 2013 were identified. Specimens obtained via endoscopy were analyzed microscopically by a pathologist. The relationship between endoscopic appearance and histopathological features was analyzed. The χ test, Fisher's exact probability test, and the Mann-Whitney U test were used.Granulomas were present in 81.3% of ITB cases and in 67.3% of CD cases (P = 0.36). Granulomas in ITB cases were denser than those in CD cases (mean 5.29 ± 4.30 vs. 2.46 ± 3.50 granulomas per 10 low power fields; each low power field = 3.80 mm; P = 0.005). Granulomas in ITB cases were larger (mean widest diameter, 508 ± 314 μm; range, 100-1100 μm) than those in CD cases (mean widest diameter, 253 ± 197 μm; range, 50-800 μm). Basal plasmacytosis was more common in CD cases than in ITB cases (77.0% vs. 37.5%, P = 0.000). Endoscopy findings such as longitudinal ulcer, aphthous ulcer, and cobblestone appearance were only seen in CD cases (34.6%, 21.2%, and 23.1%, respectively). Granulomas were detected in the majority of cases with longitudinal ulcers (88.9%). Basal plasmacytosis was exclusively detected in cases with longitudinal ulcer and a cobblestone appearance.Characteristics of granulomas maybe the most important distinguishing features between CD and ITB. However, the histopathological characteristics of both diseases may overlap on endoscopic biopsy specimens. An accurate diagnosis should be made that considers clinical, endoscopic features, and pathologic findings.
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