ArticleCortex; a journal devoted to the study of the nervous system and behavior2016
Altered functional connectivity in lesional peduncular hallucinosis with REM sleep behavior disorder.
Article in Cortex; a journal devoted to the study of the nervous system and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- Parkinson disease psychosis: from phenomenology to neurobiological mechanisms.Nature reviews. Neurology · 2024Review
- Parkinson's disease patients combined with constipation tend to have higher serum expression of microRNA 29c, prominent neuropsychiatric disorders, possible RBD conversion, and a substandard quality of life.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2023Article
- Sleep and Autonomic Manifestations in Parkinson's Disease Complicated With Probable Rapid Eye Movement Sleep Behavior Disorder.Frontiers in neuroscience · 2022Article
- Current Treatment Options for REM Sleep Behaviour Disorder.Journal of personalized medicine · 2021Review
- Neurochemical Features of Rem Sleep Behaviour Disorder.Journal of personalized medicine · 2021Review
- Lesions causing hallucinations localize to one common brain network.Molecular psychiatry · 2021Article
- Lesion network mapping: where do we go from here?Brain : a journal of neurology · 2021Article
- Article
- Dream enactment behavior: review for the clinician.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2020Article
- [Changes of brain structural network properties in patients with rapid eye movement sleep behavior disorder].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Article
- Brainstem dysfunction in critically ill patients.Critical care (London, England) · 2020Review
- Study on the Clinical Features of Parkinson's Disease With Probable Rapid Eye Movement Sleep Behavior Disorder.Frontiers in neurology · 2020Article
- Peduncular hallucinosis associated with a pontine cavernoma.Mental illness · 2018Article
- Idiopathic REM sleep behaviour disorder and neurodegeneration - an update.Nature reviews. Neurology · 2018Review
- Bridging the Great Divide: What Can Neurology Learn From Psychiatry?The Journal of neuropsychiatry and clinical neurosciences · 2018Article
- Alterations of Brain Structural Network in Parkinson's Disease With and Without Rapid Eye Movement Sleep Behavior Disorder.Frontiers in neurology · 2018Article
- A Particular Medullary-Spinal Inhibitory Pathway is Recruited for the Expression of Muscle Atonia During REM Sleep.Journal of experimental neuroscience · 2018Article
- Clinical features of Parkinson's disease with and without rapid eye movement sleep behavior disorder.Translational neurodegeneration · 2017Article
- Prediction error, ketamine and psychosis: An updated model.Journal of psychopharmacology (Oxford, England) · 2016Review
- Hallucinations as top-down effects on perception.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2016Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Brainstem lesions causing peduncular hallucinosis (PH) produce vivid visual hallucinations occasionally accompanied by sleep disorders. Overlapping brainstem regions modulate visual pathways and REM sleep functions via gating of thalamocortical networks. A 66-year-old man with paroxysmal atrial fibrillation developed abrupt-onset complex visual hallucinations with preserved insight and violent dream enactment behavior. Brain MRI showed restricted diffusion in the left rostrodorsal pons suggestive of an acute ischemic stroke. REM sleep behavior disorder (RBD) was diagnosed on polysomnography. We investigated the integrity of ponto-geniculate-occipital circuits with seed-based resting-state functional connectivity MRI (rs-fcMRI) in this patient compared to 46 controls. Rs-fcMRI revealed significantly reduced functional connectivity between the lesion and lateral geniculate nuclei (LGN), and between LGN and visual association cortex compared to controls. Conversely, functional connectivity between brainstem and visual association cortex, and between visual association cortex and prefrontal cortex (PFC) was significantly increased in the patient. Focal damage to the rostrodorsal pons is sufficient to cause RBD and PH in humans, suggesting an overlapping mechanism in both syndromes. This lesion produced a pattern of altered functional connectivity consistent with disrupted visual cortex connectivity via de-afferentation of thalamocortical pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.