ArticlePLoS genetics2015
Reproductive Aging Drives Protein Accumulation in the Uterus and Limits Lifespan in C. elegans.
Article in PLoS genetics, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 40 citations in OpenAlex.
- Deconvolution of Single-Organism Omics Resolves Cellular and Tissue Dynamics during Aging.microPublication biology · 2026Article
- Machine learning predicts lifespan and suggests underlying causes of death in aging C. elegans.Communications biology · 2025Article
- A hierarchy of causes of death in senescentbioRxiv : the preprint server for biology · 2025Article
- Multiscale patterning of a model apical extracellular matrix revealed by systematic endogenous protein tagging.bioRxiv : the preprint server for biology · 2025Article
- Doxifluridine promotes host longevity through bacterial metabolism.PLoS genetics · 2025Article
- Transcriptomic Analysis of the Spatiotemporal Axis of Oogenesis and Fertilization inbioRxiv : the preprint server for biology · 2024Article
- AdvancingPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2024Review
- Transcriptomic analysis of the spatiotemporal axis of oogenesis and fertilization inFrontiers in cell and developmental biology · 2024Article
- Combinatorial interventions in aging.Nature aging · 2023Review
- Spatial single-cell sequencing of meiosis I arrested oocytes indicates acquisition of maternal transcripts from the soma.Cell reports · 2023Article
- Aging Hallmarks and the Role of Oxidative Stress.Antioxidants (Basel, Switzerland) · 2023Review
- Vitellogenin accumulation leads to reproductive senescence by impairing lysosomal function.Science China. Life sciences · 2023Article
- AbioRxiv : the preprint server for biology · 2023Article
- Molecular basis of reproductive senescence: insights from model organisms.Journal of assisted reproduction and genetics · 2021Review
- Review
- The proteostasis network and its decline in ageing.Nature reviews. Molecular cell biology · 2019Review
- CBD-1 organizes two independent complexes required for eggshell vitelline layer formation and egg activation in C. elegans.Developmental biology · 2018Article
- A novel vibration-induced exercise paradigm improves fitness and lipid metabolism of Caenorhabditis elegans.Scientific reports · 2018Article
- Methods to Study Changes in Inherent Protein Aggregation with Age in Caenorhabditis elegans.Journal of visualized experiments : JoVE · 2017Article
- Reduced Insulin/IGF-1 Signaling Restores the Dynamic Properties of Key Stress Granule Proteins during Aging.Cell reports · 2017Article
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4 authors at 1 institution in 1 country.
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Abstract
Aging in Caenorhabditis elegans is characterized by widespread physiological and molecular changes, but the mechanisms that determine the rate at which these changes occur are not well understood. In this study, we identify a novel link between reproductive aging and somatic aging in C. elegans. By measuring global age-related changes in the proteome, we identify a previously uncharacterized group of secreted proteins in the adult uterus that dramatically increase in abundance with age. This accumulation is blunted in animals with an extended reproductive period and accelerated in sterile animals lacking a germline. Uterine proteins are not removed in old post-reproductive animals or in young vulvaless worms, indicating that egg-laying is necessary for their rapid removal in wild-type young animals. Together, these results suggest that age-induced infertility contributes to extracellular protein accumulation in the uterus with age. Finally, we show that knocking down multiple age-increased proteins simultaneously extends lifespan. These results provide a mechanistic example of how the cessation of reproduction contributes to detrimental changes in the soma, and demonstrate how the timing of reproductive decline can influence the rate of aging.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.