ArticleJournal of pediatric gastroenterology and nutrition2016
Neurodevelopmental and Cognitive Outcomes in Children With Intestinal Failure.
Article in Journal of pediatric gastroenterology and nutrition, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Neurodevelopmental outcome of patients with congenital gastrointestinal malformations: a systematic review and meta-analysis.Archives of disease in childhood. Fetal and neonatal edition · 2021Pooled it
- Cognitive assessment in children with intestinal failure on and weaned off parenteral nutrition.Journal of pediatric gastroenterology and nutrition · 2026Observational
- Transition readiness assessment in adolescents and young adults with chronic intestinal failure on home parenteral nutrition: A descriptive cross-sectional study.JPEN. Journal of parenteral and enteral nutrition · 2025Article
- Analysis of risk factors affecting psycho-behavioural development in children with short bowel syndrome.Pediatric surgery international · 2025Article
- Is neurodevelopment impaired in Brazilian children with intestinal failure on prolonged parenteral nutrition? A single center study.Pediatric surgery international · 2024Article
- Predictors of Social-Emotional Development and Adaptive Functioning in School-Age Children with Intestinal Failure.Journal of clinical psychology in medical settings · 2023Article
- Overview of Physical, Neurocognitive, and Psychosocial Outcomes in Pediatric Intestinal Failure and Transplantation.Current gastroenterology reports · 2022Review
- Neurodevelopmental and Growth Outcomes of Extremely Preterm Infants with Short Bowel Syndrome.The Journal of pediatrics · 2021Article
- Monitoring of long-term parenteral nutrition in children with intestinal failure.JGH open : an open access journal of gastroenterology and hepatology · 2019Review
- Attitudes Surrounding the Management of Neonates with Severe Necrotizing Enterocolitis.The Journal of pediatrics · 2018Article
- Neurodevelopmental, cognitive and motor function: Practice recommendations in pediatric intestinal failure and transplantation- position statement of the International Intestinal Rehabilitation and Transplant Association allied health committee.Intestinal Failure (New York, N.Y.)Article
- Motor and cognitive outcomes in pediatric intestinal failure: A longitudinal cohort study.Intestinal Failure (New York, N.Y.)Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
objectivesRecent advances in medical and surgical management have led to improved long-term survival in children with intestinal failure. Yet, limited data exist on their neurodevelopmental and cognitive outcomes. The aim of the present study was to measure neurodevelopmental outcomes in children with intestinal failure.
methodsChildren enrolled in a regional intestinal failure program underwent prospective neurodevelopmental and psychometric evaluation using a validated scoring tool. Cognitive impairment was defined as a mental developmental index <70. Neurodevelopmental impairment was defined as cerebral palsy, visual or hearing impairment, or cognitive impairment. Univariate analyses were performed using the Wilcoxon rank-sum test. Data are presented as median (range).
resultsFifteen children with a remnant bowel length of 18 (5-85) cm were studied at age 17 (12-67) months. Thirteen patients remained dependent on parenteral nutrition. Twelve (80%) subjects scored within the normal range on cognitive testing. Each child with cognitive impairment was noted to have additional risk factors independent of intestinal failure including cardiac arrest and extreme prematurity. On univariate analysis, cognitive impairment was associated with longer inpatient hospital stays, increased number of surgical procedures, and prematurity (P < 0.02). In total, 4 (27%) children demonstrated findings consistent with neurodevelopmental impairment.
conclusionsA majority of children with intestinal failure demonstrated normal neurodevelopmental and cognitive outcomes on psychometric testing. These data suggest that children with intestinal failure without significant comorbidity may be at low risk for long-term neurodevelopmental impairment.
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