ArticleAlzheimer disease and associated disorders
Influence of Perceived Stress on Incident Amnestic Mild Cognitive Impairment: Results From the Einstein Aging Study.
Article in Alzheimer disease and associated disorders. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 62 citations in OpenAlex.
- Purpose in life and stress: An individual-participant meta-analysis of 16 samples.Journal of affective disorders · 2024Pooled it
- Pain and mild cognitive impairment among adults aged 50 years and above residing in low- and middle-income countries.Aging clinical and experimental research · 2023Pooled it
- Behavioral and Psychological Symptoms that Predict Cognitive Decline or Impairment in Cognitively Normal Middle-Aged or Older Adults: a Meta-Analysis.Neuropsychology review · 2020Pooled it
- Effects of Meditation versus Music Listening on Perceived Stress, Mood, Sleep, and Quality of Life in Adults with Early Memory Loss: A Pilot Randomized Controlled Trial.Journal of Alzheimer's disease : JAD · 2016Trial
- A Taxonomy of Data Synthesis.Personality & social psychology bulletin · 2026Article
- Stress, stress systems, and Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- Purpose in life and coping strategies: Main associations and moderation by concurrent distress.PloS one · 2026Article
- Psychological Stress and Cognitive Brain Health: Policies to Reduce Dementia Risk.Policy insights from the behavioral and brain sciences · 2025Article
- Is to persevere dangerous for brain health? Effect of active coping and grit on subjective cognitive decline in Black American males.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Mitochondrial Functioning: Front and Center in Defining Psychosomatic Mechanisms of Allostasis in Health and Disease.Methods in molecular biology (Clifton, N.J.) · 2025Review
- The Effect of Psychological Resilience on Cognitive Decline in Community-Dwelling Older Adults: The Korean Frailty and Aging Cohort Study.Korean journal of family medicine · 2024Article
- Association of Stress With Cognitive Function Among Older Black and White US Adults.JAMA network open · 2023Article
- It goes both ways: The relationship between anxiety and mild cognitive impairment.International journal of geriatric psychiatry · 2023Article
- Elucidation of the mechanisms underlying tumor aggravation by the activation of stress-related neurons in the paraventricular nucleus of the hypothalamus.Molecular brain · 2023Article
- Addressing Psychosocial Factors in Cognitive Impairment Screening from a Holistic Perspective: The DeCo-Booklet Methodology Design and Pilot Study.International journal of environmental research and public health · 2022Article
- Depressive symptoms mediate the relationship between diabetes and cognitive performance in a community-based sample of older adults.Journal of diabetes and its complications · 2022Article
- A Study on the Willingness to Use Meditation for Maintaining Psychological Well-Being During the COVID-19 Pandemic.Cureus · 2022Article
- The Roles of General and Domain-Specific Perceived Stress in Healthy Aging.The journals of gerontology. Series B, Psychological sciences and social sciences · 2022Article
- In Older Adults, Perceived Stress and Self-Efficacy Are Associated with Verbal Fluency, Reasoning, and Prospective Memory (Moderated by Socioeconomic Position).Brain sciences · 2022Article
- Mindful walking and cognition in older adults: A proof of concept study using in-lab and ambulatory cognitive measures.Preventive medicine reports · 2021Article
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Stress is a potentially remediable risk factor for amnestic mild cognitive impairment (aMCI). Our objective is to determine whether perceived stress predicts incident aMCI and to determine if the influence of stress on aMCI is independent of known aMCI risk factors, particularly demographic variables, depression, and apolipoprotein genotype. The Einstein Aging Study is a longitudinal community-based study of older adults. The Perceived Stress Scale (PSS) was administered annually in the Einstein Aging Study to participants (N=507; 71 developed incident aMCI; mean follow-up time=3.6 y, SD=2.0) who were aged 70 years and older, free of aMCI and dementia at baseline PSS administration, and had at least 1 subsequent annual follow-up. Cox hazard models were used to examine time to aMCI onset adjusting for covariates. High levels of perceived stress are associated with a 30% greater risk of incident aMCI (per 5-point increase in PSS: hazard ratio=1.30; 95% confidence interval, 1.08-1.58) independent of covariates. The consistency of results after covariate adjustment and the lack of evidence for reverse causation in longitudinal analyses suggest that these findings are robust. Understanding of the effect of perceived stress on cognition may lead to intervention strategies that prevent the onset of aMCI and Alzheimer dementia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.