Evidence map›Paper›PMID 26654786›Full record

Trial reportNeuroImage2016

Multi-modal characterization of rapid anterior hippocampal volume increase associated with aerobic exercise.

Adam G Thomas, Andrea Dennis, Nancy B Rawlings, Charlotte J Stagg, Lucy Matthews, Martyn Morris, Shannon H Kolind, Sean Foxley, Mark Jenkinson, Thomas E Nichols and 3 more

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in NeuroImage, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
82citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

82 citing papers in PubMed, 5 syntheses or guidelines pooled it.

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22 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Adam G ThomasSection on Functional Imaging Methods, NIMH, NIH, DHHS, Bethesda, MD, USA; FMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom. Electronic address: adamt@nih.gov.
Andrea DennisFMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Nancy B RawlingsFMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Charlotte J StaggFMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Lucy MatthewsFMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Martyn MorrisMovement Sciences Group, Oxford Brookes University, Oxford, United Kingdom.
Shannon H KolindCenter for Neuroimaging Sciences, King's College London, London, ON, Canada.
Sean FoxleyFMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Mark JenkinsonFMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.
Thomas E NicholsDepartment of Statistics, University of Warwick, Coventry, United Kingdom.
Helen DawesDepartment of Statistics, University of Warwick, Coventry, United Kingdom.
Peter A BandettiniSection on Functional Imaging Methods, NIMH, NIH, DHHS, Bethesda, MD, USA.
Heidi Johansen-BergFMRIB, Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, United Kingdom.

Funding

Functional MRI Method DevelopmentZIAMH002783 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI BANDETTINI, PETER · 2009 to 2025
$38.4M
Data Science and Sharing TeamZICMH002960 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI THOMAS, ADAM G · 2017 to 2025
$10.3M
Intramural NIH HHS Z99 MH999999Medical Research Council G0901996Wellcome Trust 090955Wellcome Trust 100309Wellcome Trust 102584
6 · The paper itself

Abstract

The hippocampus has been shown to demonstrate a remarkable degree of plasticity in response to a variety of tasks and experiences. For example, the size of the human hippocampus has been shown to increase in response to aerobic exercise. However, it is currently unknown what underlies these changes. Here we scanned sedentary, young to middle-aged human adults before and after a six-week exercise intervention using nine different neuroimaging measures of brain structure, vasculature, and diffusion. We then tested two different hypotheses regarding the nature of the underlying changes in the tissue. Surprisingly, we found no evidence of a vascular change as has been previously reported. Rather, the pattern of changes is better explained by an increase in myelination. Finally, we show that hippocampal volume increase is temporary, returning to baseline after an additional six weeks without aerobic exercise. This is the first demonstration of a change in hippocampal volume in early to middle adulthood suggesting that hippocampal volume is modulated by aerobic exercise throughout the lifespan rather than only in the presence of age related atrophy. It is also the first demonstration of hippocampal volume change over a period of only six weeks, suggesting that gross morphometric hippocampal plasticity occurs faster than previously thought.

Indexed as

AdultAgingBlood Flow VelocityCerebrovascular CirculationExerciseFemaleHippocampusHumansMaleMultimodal ImagingNeuroimagingNeuronal PlasticityOrgan SizePhysical Conditioning, HumanAgingAngiogenesisDentate gyrusEnvironmental enrichmentExerciseFitnessHippocampusMyelinNeurogenesisPlasticity

Identifiers

PMID26654786
PMCPMC4848119

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.