Evidence map›Paper›PMID 26654720›Full record

Trial reportBMC psychiatry2015

Wellbeing and resilience: mechanisms of transmission of health and risk in parents with complex mental health problems and their offspring--The WARM Study.

Susanne Harder, Kirstine Davidsen, Angus MacBeth, Theis Lange, Helen Minnis, Marianne Skovsager Andersen, Erik Simonsen, Jenna-Marie Lundy, Maja Nyström-Hansen, Christopher Høier Trier and 2 more

Registry-linked trialOpen access · goldAbstract readClinical Trial
In one paragraph

Trial report in BMC psychiatry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02306551 (Well Being And Resilience), which is not on this map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.9field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02306551 completednot on this map

Well Being And Resilience: Mechanisms of Transmission of Health and Risk in Parents With Complex Mental Health Problems and Their Offspring

TypeobservationalSponsorSusanne HarderRan2014 to 2021Enrolled93ConditionsPsychotic Disorder, Bipolar Disorder, Depressive DisorderArmsBiological and psycho-social risk and resilience factors
3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 24 citations in OpenAlex.

  1. Pooled it
  2. Review
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  10. Autism: a transdiagnostic, dimensional, construct of reasoning?The European journal of neuroscience · 2018
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 2 countries.

Susanne HarderDepartment of Psychology, University of Copenhagen, Copenhagen, Denmark. Susanne.Harder@psy.ku.dk.
Kirstine DavidsenDepartment of Child and Adolescent Mental Health Odense, Research Unit, Mental Health Services in the Region of Southern Denmark, Middelfart, Denmark. Kirstine.Agnete.Davidsen@rsyd.dk.
Angus MacBethSchool of Health in Social Science, University of Edinburgh, Edinburgh, Scotland, UK. amacbeth@exseed.ed.ac.uk.
Theis LangeDepartment of Public Health, Section of Biostatistics, University of Copenhagen, Copenhagen, Denmark. thlan@sund.ku.dk.
Helen MinnisInstitute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK. Helen.Minnis@glasgow.ac.uk.
Marianne Skovsager AndersenUniversity of Southern Denmark, Odense, Denmark. Marianne.Andersen1@rsyd.dk.
Erik SimonsenPsychiatric Research Unit, Psychiatry, Region Zealand, Roskilde, Denmark.
Jenna-Marie LundyInstitute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK. Jenna-Marie.Lundy@glasgow.ac.uk.
Maja Nyström-HansenDepartment of Psychology, University of Copenhagen, Copenhagen, Denmark. maja.hansen@psy.ku.dk.
Christopher Høier TrierDepartment of Psychology, University of Copenhagen, Copenhagen, Denmark. christopher.trier@psy.ku.dk.
Katrine RøhderDepartment of Psychology, University of Copenhagen, Copenhagen, Denmark. katrine.rohder@psy.ku.dk.
Andrew GumleyInstitute of Health and Wellbeing, University of Glasgow, Glasgow, Scotland, UK. Andrew.Gumley@glasgow.ac.uk.
University of Copenhagen · DKUniversity of Glasgow · GBRegion of Southern Denmark · DKRegion Zealand · DKUniversity of Edinburgh · GBUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledThe WARM study is a longitudinal cohort study following infants of mothers with schizophrenia, bipolar disorder, depression and control from pregnancy to infant 1 year of age.

backgroundChildren of parents diagnosed with complex mental health problems including schizophrenia, bipolar disorder and depression, are at increased risk of developing mental health problems compared to the general population. Little is known regarding the early developmental trajectories of infants who are at ultra-high risk and in particular the balance of risk and protective factors expressed in the quality of early caregiver-interaction. METHODS/

designWe are establishing a cohort of pregnant women with a lifetime diagnosis of schizophrenia, bipolar disorder, major depressive disorder and a non-psychiatric control group. Factors in the parents, the infant and the social environment will be evaluated at 1, 4, 16 and 52 weeks in terms of evolution of very early indicators of developmental risk and resilience focusing on three possible environmental transmission mechanisms: stress, maternal caregiver representation, and caregiver-infant interaction. DISCUSSION: The study will provide data on very early risk developmental status and associated psychosocial risk factors, which will be important for developing targeted preventive interventions for infants of parents with severe mental disorder.

trial registrationNCT02306551, date of registration November 12, 2014.

Indexed as

Resilience, PsychologicalAdultBipolar DisorderChildChild of Impaired ParentsCohort StudiesComorbidityDevelopmental DisabilitiesFemaleHumansInfantLongitudinal StudiesMajor Depressive DisorderMaleMental DisordersMental Health

Identifiers

PMID26654720
PMCPMC4674908
OpenAlexW2190537451

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.