Evidence map›Paper›PMID 26654374›Full record

ArticleCurrent biology : CB2015

Signal Transduction: Gain of Activin Turns Muscle into Bone.

Gonzalo Sanchez-Duffhues, Theodore Fotsis, Peter ten Dijke

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 3 countries.

Gonzalo Sanchez-DuffhuesDepartment of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, The Netherlands.
Theodore FotsisDepartment of Biomedical Research, Institute of Molecular Biology & Biotechnology, FORTH & Laboratory of Biological Chemistry, Medical School, University of Ioannina, University Campus, University of Ioannina, 45110 Ioannina, Greece. Currently: Visiting Professor, School of Biosciences, College of Life and Environmental Sciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK.
Peter ten DijkeDepartment of Molecular Cell Biology, Cancer Genomics Centre Netherlands, Leiden University Medical Center, The Netherlands. Electronic address: P.ten_Dijke@lumc.nl.
Leiden University Medical Center · NLUniversity of Ioannina · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Recent data provide an unexpected twist in our understanding of the pathogenesis of fibrodysplasia ossificans progressiva. Surprisingly, the causative amino acid mutation of the BMP receptor responds to activin, thereby turning soft tissues into bone.

Indexed as

MutationActivin Receptors, Type IActivinsAnimalsMyositis OssificansActivin Receptors, Type IActivins

Identifiers

PMID26654374
OpenAlexW2192479565

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.