ArticleBMC research notes2015
Association of methylenetetrahydrofolate reductase gene (C677T) with the risk of hypertension in Morocco.
Article in BMC research notes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Association Between Folate and Health Outcomes: An Umbrella Review of Meta-Analyses.Frontiers in public health · 2020Pooled it
- Evidence on the causal link between homocysteine and hypertension from a meta-analysis of 40 173 individuals implementing Mendelian randomization.Journal of clinical hypertension (Greenwich, Conn.) · 2019Pooled it
- Genetic factors contributing to hypertension in African-based populations: A systematic review and meta-analysis.Journal of clinical hypertension (Greenwich, Conn.) · 2018Pooled it
- Genetic Variants in the MTHFR and WNK1 Genes and Their Contribution to Hypertension Susceptibility.International journal of medical sciences · 2026Article
- Genetic Factors Contributing to the Pathogenesis of Essential Hypertension in Two African Populations.Journal of personalized medicine · 2024Article
- Association study between genetic polymorphisms in MTHFR and stroke susceptibility in Egyptian population: a case-control study.Scientific reports · 2024Article
- Susceptibility to hypertension based onFrontiers in cardiovascular medicine · 2023Article
- Review
- Review
- The association ofFrontiers in genetics · 2022Article
- The protective effects of the methylenetetrahydrofolate reductase rs1801131 variant among Saudi smokers.Saudi journal of biological sciences · 2021Article
- Review
- Association BetweenFrontiers in genetics · 2021Review
- Polymorphism of MTHFR C677T Gene and the Associations with the Severity of Essential Hypertension in Northern Chinese Population.International journal of hypertension · 2020Article
- Association of single nucleotide polymorphisms of MTHFR, TCN2, RNF213 with susceptibility to hypertension and blood pressure.Bioscience reports · 2019Article
- The Role of Polymorphism GenOpen access Macedonian journal of medical sciences · 2019Article
- Analysis of genetic polymorphism of methylenetetrahydrofolate reductase in a large ethnic Hakka population in southern China.Medicine · 2018Article
- Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHypertension is a multifactorial disease caused by the interaction between genetic and environmental factors. Mutations in the methylenetetrahydrofolate reductase gene (MTHFR) have been known to be associated with the risk of cardiovascular disease as well as hypertension. This case-control study was conducted out to measure the association of the polymorphism C677T of MTHFR with the risk of hypertension.
methodsPolymerase chain reaction followed by restriction fragment analysis length was used to identify MTHFR C677T genotypes in patients 101 patients and 102 age and sex matched healthy controls. Odds ratio with 95 % confidence interval was used to assess the risk of association.
resultsThe distribution of demographic and clinical features of patients showed no particular trend (p > 0.05). However, the frequency of homozygous 677T allele was higher in patients with a family history of heart disease (30.4 vs. 9 %, p = 0.031). Interestingly, the mutant 677TT genotype was significantly associated with the susceptibility of hypertension when compared to the wild type 677CC genotype (OR 5.4, CI 1.4-19.8, p = 0.008). In addition, the recessive model 677TT vs. 677CC/CT was found to be associated with the risk of hypertension (OR 5.3, CI 1.5-19.1, p = 0.005). However, the dominant model was not associated with the risk of hypertension in our cohort (OR 1.3, CI 0.7-2.2, p = 0.4).
conclusionsBased on our findings, the homozygous mutant for 677TT of MTHFR gene is associated with the risk of hypertension in our population. Further studies with larger sample sizes are needed to confirm the results of this study.
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