ArticleArthritis research & therapy2015
A low cortisol response to stress is associated with musculoskeletal pain combined with increased pain sensitivity in young adults: a longitudinal cohort study.
Article in Arthritis research & therapy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- Pooled it
- Construction of a Modified Pain-Induced Stress White Hair Model.Experimental dermatology · 2026Article
- Perceived control as a resilience factor: associations with neural, physiological and affective stress responses and mental health.Translational psychiatry · 2026Article
- Biological Markers of Musculoskeletal Pain: A Scoping Review.Journal of pain research · 2024Article
- Forced swim stress exacerbates inflammation-induced hyperalgesia and oxidative stress in the rat trigeminal ganglia.Frontiers in pain research (Lausanne, Switzerland) · 2024Article
- The Biology of Stress Intolerance in Patients with Chronic Pain-State of the Art and Future Directions.Journal of clinical medicine · 2023Review
- Sex differences in factors associated with neck pain among undergraduate healthcare students: a cross-sectional survey.BMC musculoskeletal disorders · 2022Article
- Serum Concentrations of the Endocannabinoid, 2-Arachidonoylglycerol, in the Peri-Trauma Period Are Positively Associated with Chronic Pain Months Later.Biomedicines · 2022Article
- The relationship between chronotypes and musculoskeletal problems in male automobile manufacturing workers.Annals of occupational and environmental medicine · 2021Article
- Can cortisol levels predict the severity of acute whiplash-associated disorders?European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2020Observational
- Walking the Tightrope: A Proposed Model of Chronic Pain and Stress.Frontiers in neuroscience · 2020Review
- Transitioning from acute to chronic pain: a simulation study of trajectories of low back pain.Journal of translational medicine · 2019Article
- The Effects Induced by Spinal Manipulative Therapy on the Immune and Endocrine Systems.Medicina (Kaunas, Lithuania) · 2019Review
- Is There Support for the Paradigm 'Spinal Posture as a Trigger for Episodic Headache'? A Comprehensive Review.Current pain and headache reports · 2019Review
- [Epigenetics : Important aspects for anesthesiologists, pain and intensive care physicians].Der Anaesthesist · 2018Review
- Association between cortisol levels and pain threshold in systemic sclerosis and major depression.Rheumatology international · 2018Observational
- An Integrated Model of Chronic Whiplash-Associated Disorder.The Journal of orthopaedic and sports physical therapy · 2017Article
- Depressive symptom composites associated with cortisol stress reactivity in adolescents.Journal of affective disorders · 2017Article
- Lifetime Modulation of the Pain SystemFrontiers in immunology · 2017Review
- Perinatal Depression, Adverse Life Events, and Hypothalamic-Adrenal-Pituitary Axis Response to Cold Pressor Stress in Latinas: An Exploratory Study.Women's health issues : official publication of the Jacobs Institute of Women's HealthArticle
Corrections and comments
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Authors and funding
8 authors at 4 institutions in 2 countries.
Funding
Abstract
backgroundIn this study, we investigated whether an abnormal hypothalamic-pituitary-adrenal (HPA) axis response to psychosocial stress at 18 years of age is associated with musculoskeletal (MS) pain alone and MS pain combined with increased pain sensitivity at 22 years of age.
methodsThe study sample included 805 participants from the Western Australian Pregnancy Cohort (Raine) Study who participated in the Trier Social Stress Test (TSST) at age 18 years. Number of pain sites, pain duration, pain intensity and pain frequency were assessed at age 22 to measure severity of MS pain. Cold and pressure pain thresholds were determined at age 22. Group-based trajectory modeling was applied to establish cortisol response patterns based on the TSST. Logistic regression was used to study the association of TSST patterns with MS pain alone and MS pain combined with increased cold or pressure pain sensitivity, adjusted for relevant confounding factors. All analyses were stratified by sex.
resultsThe mean (standard deviation) age during the TSST was 18.3 (0.3) years, and during MS pain assessment it was 22.2 (0.6). Forty-five percent of the participants were female. Three cortisol response patterns were identified, with cluster 1 (34 % of females, 21 % of males) reflecting hyporesponse, cluster 2 (47 %, 54 %) reflecting intermediate response and cluster 3 (18 %, 24 %) reflecting hyperresponse of the HPA axis. MS pain was reported by 42 % of females and 33 % of males at age 22 years. Compared with females in cluster 2, females in cluster 1 had an increased likelihood of having any MS pain (odds ratio 2.3, 95 % confidence interval 1.0-5.0) and more severe MS pain (2.8, 1.1-6.8) if their cold pain threshold was above the median. In addition, females in cluster 1 had an increased likelihood (3.5, 1.3-9.7) of having more severe MS pain if their pressure pain threshold was below the median. No statistically significant associations were observed in males.
conclusionsThis study suggests that a hyporesponsive HPA axis at age 18 years is associated with MS pain at 22 years in young females with increased pain sensitivity.
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