ArticleMutation research. Genetic toxicology and environmental mutagenesis2015
Sperm DNA oxidative damage and DNA adducts.
Article in Mutation research. Genetic toxicology and environmental mutagenesis, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.
- Association between exposure to polycyclic aromatic hydrocarbons and reproductive health outcomes: a systematic review and meta-analysis.Journal of health, population, and nutrition · 2025Pooled it
- Endocrine Disrupting Agents: Toxicological Aspects on Male Reproduction.Reproductive sciences (Thousand Oaks, Calif.) · 2025Review
- Determination of Ram (Animals : an open access journal from MDPI · 2022Article
- Effect of Sperm 26S Proteasome on Embryo Formation and Development in In Vitro Fertilization.Reproductive sciences (Thousand Oaks, Calif.) · 2022Article
- Exposure to polycyclic aromatic hydrocarbons and nicotine, and associations with sperm DNA fragmentation.Andrology · 2022Article
- Reassessing the interpretation of oxidation-reduction potential in male infertility.Reproduction & fertility · 2022Article
- Mixture Analysis of Associations between Occupational Exposure to Polycyclic Aromatic Hydrocarbons and Sperm Oxidative DNA Damage.Annals of work exposures and health · 2022Article
- Dehydroepiandrosterone modulates oxidative DNA damage in pancreatic cancer: A case-control study.JGH open : an open access journal of gastroenterology and hepatology · 2021Article
- Oxidation of Sperm DNA and Male Infertility.Antioxidants (Basel, Switzerland) · 2021Review
- Zinc oxide nanoparticles and L-carnitine effects on neuro-schistosomiasis mansoni induced in mice.Environmental science and pollution research international · 2020Article
- Nitric oxide, 8-hydroxydeoxyguanosine, and total antioxidant capacity in human seminal plasma of infertile men and their relationship with sperm parameters.Clinical and experimental reproductive medicine · 2020Article
- The Potential Role of Seminal Plasma in the Fertilization Outcomes.BioMed research international · 2019Review
- Acrosome reaction and chromatin integrity as additional parameters of semen analysis to predict fertilization and blastocyst rates.Reproductive biology and endocrinology : RB&E · 2018Article
- Environmental PAH exposure and male idiopathic infertility: a review on early life exposures and adult diagnosis.Reviews on environmental health · 2017Review
- Exploring the Mechanisms of Yishen Tongluo Decoction on Repairing DNA Damage in Mouse Spermatogonia Cells Based on Whole Transcriptome Sequencing.American journal of men's healthArticle
Corrections and comments
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Authors and funding
4 authors at 4 institutions in 2 countries.
Funding
Abstract
The objective of this study was to investigate DNA damage and adducts in sperm from coke oven workers who have been exposed to polycyclic aromatic hydrocarbons. A longitudinal study was conducted with repeated measurements during spermatogenesis. Coke-oven workers (n=112) from a coke-oven plant served the PAH-exposed group, while administrators and security personnel (n=67) served the control. Routine semen parameters (concentration, motility, vitality, and morphology) were analyzed simultaneously; the assessment of sperm DNA integrity endpoints included DNA fragmentation, bulky DNA adducts, and 8-oxo-7,8-dihydro-2'-deoxyguanosine (8-oxo-dGuo). The degree of sperm DNA fragmentation was measured using the terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling (TUNEL) assay and sperm chromatin structure assay (SCSA). The PAH-exposed group had a significant increase in bulky DNA adducts and 8-oxo-dGuo compared to the control subjects (Ps=0.002 and 0.045, respectively). Coke oven workers' percentages of DNA fragmentation and denaturation from the PAH-exposed group were not significantly different from those of the control subjects (Ps=0.232 and 0.245, respectively). Routine semen parameters and DNA integrity endpoints were not correlated. Concentrations of 8-oxo-dGuo were positively correlated with percentages of DNA fragmentation measured by both TUNEL and SCSA (Ps=0.045 and 0.034, respectively). However, the concentrations of 8-oxo-dGuo and percentages of DNA fragmentation did not correlate with concentrations of bulky DNA adducts. In summary, coke oven workers with chronic exposure to PAHs experienced decreased sperm DNA integrity. Oxidative stress could contribute to the degree of DNA fragmentation. Bulky DNA adducts may be independent of the formation of DNA fragmentation and oxidative adducts in sperm. Monitoring sperm DNA integrity is recommended as a part of the process of assessing the impact of occupational and environmental toxins on sperm.
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