ArticleeLife2015
The carcinine transporter CarT is required in Drosophila photoreceptor neurons to sustain histamine recycling.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 46 citations in OpenAlex.
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- Sensory quiescence induces a cell-non-autonomous integrated stress response curbed by condensate formation of the ATF4 and XRP1 effectors.Nature communications · 2025Article
- Histamine synthesis and transport are coupled in axon terminals via a dual quality control system.The EMBO journal · 2024Article
- A niche-derived nonribosomal peptide triggers planarian sexual development.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- A Closer Look at Histamine inInternational journal of molecular sciences · 2024Review
- A niche-derived non-ribosomal peptide triggers planarian sexual development.bioRxiv : the preprint server for biology · 2023Article
- Visual impairment cell non-autonomously dysregulates brain-wide proteostasis.bioRxiv : the preprint server for biology · 2023Article
- Allnighter pseudokinase-mediated feedback links proteostasis and sleep in Drosophila.Nature communications · 2023Article
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- A phosphoswitch at acinus-serineeLife · 2022Article
- Histamine, Neuroinflammation and Neurodevelopment: A Review.Frontiers in neuroscience · 2021Review
- L-Carnitine in Drosophila: A Review.Antioxidants (Basel, Switzerland) · 2020Review
- Vesicular neurotransmitter transporters in Drosophila melanogaster.Biochimica et biophysica acta. Biomembranes · 2020Review
- Histaminergic Control of Corticostriatal Synaptic Plasticity during Early Postnatal Development.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
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- Yorkie Growth-Promoting Activity Is Limited by Atg1-Mediated Phosphorylation.Developmental cell · 2020Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Synaptic transmission from Drosophila photoreceptors to lamina neurons requires recycling of histamine neurotransmitter. Synaptic histamine is cleared by uptake into glia and conversion into carcinine, which functions as transport metabolite. How carcinine is transported from glia to photoreceptor neurons remains unclear. In a targeted RNAi screen for genes involved in this pathway, we identified carT, which encodes a member of the SLC22A transporter family. CarT expression in photoreceptors is necessary and sufficient for fly vision and behavior. Carcinine accumulates in the lamina of carT flies. Wild-type levels are restored by photoreceptor-specific expression of CarT, and endogenous tagging suggests CarT localizes to synaptic endings. Heterologous expression of CarT in S2 cells is sufficient for carcinine uptake, demonstrating the ability of CarT to utilize carcinine as a transport substrate. Together, our results demonstrate that CarT transports the histamine metabolite carcinine into photoreceptor neurons, thus contributing an essential step to the histamine-carcinine cycle.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.