ArticleMicrobiome2015
Simultaneous fecal microbial and metabolite profiling enables accurate classification of pediatric irritable bowel syndrome.
Article in Microbiome, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03653689 (Molecular Phenotyping of IBS Subtypes), which is not on this map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Molecular Phenotyping of IBS Subtypes
Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- A Systematic Review: Fecal Bacterial Profile in Patients with Irritable Bowel Syndrome Analyzed with the GA-Map Dysbiosis Test Based on the 16S rRNA Gene of Bacterial Species or Groups.Clinical and experimental gastroenterology · 2024Review
- Profiling of the fecal microbiota and circulating microRNA-16 in IBS subjects with Blastocystis infection : a case-control study.European journal of medical research · 2023Article
- Fecal Microbial Composition and Predicted Functional Profile in Irritable Bowel Syndrome Differ between Subtypes and Geographical Locations.Microorganisms · 2023Article
- Alterations in the Fecal Microbiota Composition in Pediatric Acute Diarrhea: A Cross-Sectional and Comparative Study of Viral and Bacterial Enteritis.Infection and drug resistance · 2023Article
- Functional Gastrointestinal Disorders with Psychiatric Symptoms: Involvement of the Microbiome-Gut-Brain Axis in the Pathophysiology and Case Management.Microorganisms · 2022Review
- Article
- Gut Microbiota Shifting in Irritable Bowel Syndrome: The Mysterious Role ofFrontiers in medicine · 2022Review
- Article
- Functional Gastrointestinal Disorders and the Microbiome-What Is the Best Strategy for Moving Microbiome-based Therapies for Functional Gastrointestinal Disorders into the Clinic?Gastroenterology · 2021Article
- Systematic Metabolic Profiling of Mice with Dextran Sulfate Sodium-Induced Colitis.Journal of inflammation research · 2021Article
- Microbial and metabolomic profiles in correlation with depression and anxiety co-morbidities in diarrhoea-predominant IBS patients.BMC microbiology · 2020Article
- Prevention of excessive exercise-induced adverse effects in rats with Bacillus subtilis BSB3.Journal of applied microbiology · 2020Article
- Autism Spectrum Disorder as a Brain-Gut-Microbiome Axis Disorder.Digestive diseases and sciences · 2020Review
- Altered profiles of fecal metabolites correlate with visceral hypersensitivity and may contribute to symptom severity of diarrhea-predominant irritable bowel syndrome.World journal of gastroenterology · 2019Article
- Leveraging Human Microbiome Features to Diagnose and Stratify Children with Irritable Bowel Syndrome.The Journal of molecular diagnostics : JMD · 2019Article
- Mixed Viral-Bacterial Infections and Their Effects on Gut Microbiota and Clinical Illnesses in Children.Scientific reports · 2019Article
- The Gut Microbiome in Adult and Pediatric Functional Gastrointestinal Disorders.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2019Review
- Mind-Body Interventions for Pediatric Inflammatory Bowel Disease.Children (Basel, Switzerland) · 2017Review
- Why Are Omics Technologies Important to Understanding the Role of Nutrition in Inflammatory Bowel Diseases?International journal of molecular sciences · 2016Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundWe previously showed that stool samples of pre-adolescent and adolescent US children diagnosed with diarrhea-predominant IBS (IBS-D) had different compositions of microbiota and metabolites compared to healthy age-matched controls. Here we explored whether observed fecal microbiota and metabolite differences between these two adolescent populations can be used to discriminate between IBS and health.
findingsWe constructed individual microbiota- and metabolite-based sample classification models based on the partial least squares multivariate analysis and then applied a Bayesian approach to integrate individual models into a single classifier. The resulting combined classification achieved 84 % accuracy of correct sample group assignment and 86 % prediction for IBS-D in cross-validation tests. The performance of the cumulative classification model was further validated by the de novo analysis of stool samples from a small independent IBS-D cohort.
conclusionHigh-throughput microbial and metabolite profiling of subject stool samples can be used to facilitate IBS diagnosis.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.