ArticleBehavioral neuroscience2016
Sex differences in a rat model of risky decision making.
Article in Behavioral neuroscience, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 115 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
115 citing papers in PubMed, 183 citations in OpenAlex.
- Sex-specific effects of the atypical antipsychotic risperidone on performance in a risky decision-making task.Behavioural brain research · 2027Article
- Robust effects of food deprivation as a relapse trigger: comparison to other stressors, and investigation of predictive individual traits in male and female rats.Psychopharmacology · 2026Article
- Sex-dependent role of the ventral hippocampus, but not its projection to the medial prefrontal cortex, in a novel operant conflict-driven ethanol choice task.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- A Selective Cortico-Limbic Network Organizes Behavior During Reward Seeking Under Threat.Journal of neuroscience research · 2026Article
- Contributions of the interaction between mu-opioid receptors and dopamine receptors in the regulation of risky decision making.Progress in neuro-psychopharmacology & biological psychiatry · 2026Article
- Diazepam selectively biases approach during threat-reward conflict while sparing reactive avoidance.Psychopharmacology · 2026Article
- Basolateral amygdala dopamine transmits emotional salience.Nature communications · 2026Article
- The role of ovarian hormones in risk aversion in female rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Assessing behavioral reallocation after acute environmental manipulations using an asymmetric cocaine versus sucrose choice task in male and female rats.Psychopharmacology · 2026Article
- The Role of the Posterior Paraventricular Nucleus of the Thalamus in Food Deprivation-Induced Heroin-Seeking Relapse, in Male and Female Rats.Addiction biology · 2026Article
- Female rats adopt a safety-first strategy in a high-conflict platform mediated avoidance task.Frontiers in behavioral neuroscience · 2026Article
- Dysregulation of Hedonic Processing in Chronic Pain: Insights from Preclinical Data.Brain sciences · 2025Review
- Assessing behavioral reallocation after acute environmental manipulations using an asymmetric cocaine versus sucrose choice task in male and female rats.Research square · 2025Article
- A novel cost-benefit decision-making task involving cued punishment: Effects of sex and psychostimulant administration.Behavioural brain research · 2025Article
- Low affinity noradrenergic signaling promotes passive coping during reinforcement behavior.bioRxiv : the preprint server for biology · 2025Article
- Neuromodulation of Dopamine D2 Receptors Alters Orbitofrontal Neuronal Activity and Reduces Risk-Prone Behavior in Male Rats with Inflammatory Pain.Molecular neurobiology · 2025Article
- Effects of systemic oxytocin receptor activation and blockade on risky decision making in female and male rats.Behavioral neuroscience · 2025Article
- Relative to females, male rats are more willing to forego obtaining sucrose reward in order to prevent harm to their cage mate.Psychopharmacology · 2025Article
- Effects of sex and estrous cycle on action-outcome contingencies.Behavioural brain research · 2025Article
- Adolescent THC impacts on mPFC dopamine-mediated cognitive processes in male and female rats.Psychopharmacology · 2025Article
55 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Many debilitating psychiatric conditions, including drug addiction, are characterized by poor decision making and maladaptive risk-taking. Recent research has begun to probe this relationship to determine how brain mechanisms mediating risk-taking become compromised after chronic drug use. Currently, however, the majority of work in this field has used male subjects. Given the well-established sex differences in drug addiction, it is conceivable that such differences are also evident in risk-based decision making. To test this possibility, male and female adult rats were trained in a risky decision making task (RDT), in which they chose between a small, "safe" food reward and a large, "risky" food reward accompanied by an increasing probability of mild footshock punishment. Consistent with findings in human subjects, females were more risk averse, choosing the large, risky reward significantly less than males. This effect was not due to differences in shock reactivity or body weight, and risk-taking in females was not modulated by estrous phase. Systemic amphetamine administration decreased risk-taking in both males and females; however, females exhibited greater sensitivity to amphetamine, suggesting that dopaminergic signaling may partially account for sex differences in risk-taking. Finally, although males displayed greater instrumental responding for food reward, reward choice in the RDT was not affected by satiation, indicating that differences in motivation to obtain food reward cannot fully account for sex differences in risk-taking. These results should prove useful for developing targeted treatments for psychiatric conditions in which risk-taking is altered and that are known to differentially affect males and females.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.