Evidence map›Paper›PMID 26652982›Full record

SynthesisCritical reviews in oncology/hematology2016

Natural products and complementary therapies for chemotherapy-induced peripheral neuropathy: A systematic review.

Cloé Brami, Ting Bao, Gary Deng

2 registry-linked trialsAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Critical reviews in oncology/hematology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 58 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed, 7 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05798884 naunknown statusnot on this mapstarted 2023, after this paper: background citation

Electro-acupuncture for the Prevention and Treatment of Oxaliplatin-induced Neurotoxicity in Colorectal Cancer Patients: a Prospective, Randomized, Sham-controlled, Double-blinded and Multicenter Study

TypeinterventionalSponsorHong Kong Baptist UniversityRan2023 to 2025Enrolled150ConditionsColorectal Cancer, Oxaliplatin, Electro-acupuncture, NeurotoxicityArmsAcupuncture, Sham-acupuncture
NCT06834685 narecruitingnot on this mapstarted 2025, after this paper: background citation

Evaluating Laser Photobiomodulation for the Treatment of Neuropathic Pain in Chemotherapy-induced Peripheral Neuropathy: a Randomized, Non-comparative, Placebo-controlled, Single-blinded, Phase II Clinical Trial in Cancer Patients

TypeinterventionalSponsorInstitut du Cancer de Montpellier - Val d'AurelleRan2025 to 2028Enrolled70ConditionsCancer Survivors, Peripheral Neuropathic PainArmsPhotobiomodulation sessions
3 · Its place in the literature

Who cites it

58 citing papers in PubMed, 7 syntheses or guidelines pooled it, 139 citations in OpenAlex.

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  11. Effects of exercise during chemotherapy on chemotherapy-induced peripheral neuropathy: a multicenter, randomized controlled trial.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2018
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Cloé BramiHôpital St. Louis, APHP, Department of Oncology, 1 Avenue Claude Vellefaux, 75010 Paris, France. Electronic address: cloebrami@gmail.com.
Ting BaoMemorial Sloan Kettering Cancer Center, Integrative Medicine and Breast Oncology Services, 1429 First Avenue, New York, NY 10021, United States. Electronic address: baot@mskcc.org.
Gary DengMemorial Sloan Kettering Cancer Center, Integrative Medicine Service, 1429 First Avenue, New York, NY 10021, United States. Electronic address: dengg@mskcc.org.
Memorial Sloan Kettering Cancer Center · USAssistance Publique – Hôpitaux de Paris · FR

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Acupuncture to Prevent Chemotherapy Dose ReductionR21CA173263 · NCI · UNIVERSITY OF MARYLAND BALTIMORE · PI BAO, TING · 2013 to 2014
$349k
NCI NIH HHS P30 CA008748NCI NIH HHS R21 CA173263
6 · The paper itself

Abstract

Chemotherapy-induced peripheral neuropathy (CIPN) is a serious dose-limiting side-effect without any FDA-approved treatment option. Prior reviews focus mostly on pharmacological interventions, but nonpharmaceutical interventions have also been evaluated. A Web of Science and PubMed database search to identify relevant RCTs from January 2005 to May 2015 included the terms: CIPN, cancer; and supplements, vitamin E, goshajinkigan, kampo, acetyl-L-carnitine, carnitine, alpha-lipoic acid, omega-3, glutamine, or glutamate; or massage, acupuncture, mind-body practice, yoga, meditation, Tai-Chi, physical activity, or exercise. Of 1465 publications screened, 12 RCTs evaluated natural products and one evaluated electroacupuncture. Vitamin E may help prevent CIPN. L-Glutamine, goshajinkigan, and omega-3 are also promising. Acetyl-L-carnitine may worsen CIPN and alpha-lipoic acid activity is unknown. Electroacupuncture was not superior to placebo. No RCTs were published regarding other complementary therapies, although some studies mention positive incidental findings. Natural products and complementary therapies deserve further investigation, given the lack of effective CIPN interventions.

Indexed as

Complementary TherapiesAcupuncture TherapyAntineoplastic AgentsBiological ProductsDietary SupplementsExerciseFatty Acids, Omega-3GlutamineHumansPeripheral Nervous System DiseasesVitamin EAntineoplastic AgentsBiological ProductsFatty Acids, Omega-3GlutamineVitamin EChemotherapyComplementary therapiesDietary supplementsIntegrative medicineNatural productsPeripheral neuropathyPlatinum drugsRandomized controlled trials

Identifiers

PMID26652982
PMCPMC4727999
OpenAlexW2188888880

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.