Evidence map›Paper›PMID 26652749›Full record

SynthesisSystematic reviews2015

Descending pain modulation in irritable bowel syndrome (IBS): a systematic review and meta-analysis.

Rosemary J Chakiath, Philip J Siddall, John E Kellow, Julia M Hush, Mike P Jones, Anna Marcuzzi, Paul J Wrigley

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Systematic reviews, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Review
  3. Review
  4. From the Bottom-Up: Chemotherapy and Gut-Brain Axis Dysregulation.Frontiers in behavioral neuroscience · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Rosemary J ChakiathSydney Medical School Northern, University of Sydney, Sydney, NSW, Australia. rosemary.chakiath@sydney.edu.au.
Philip J SiddallSydney Medical School Northern, University of Sydney, Sydney, NSW, Australia. psiddall@hammond.com.au.
John E KellowSydney Medical School Northern, University of Sydney, Sydney, NSW, Australia. john.kellow@sydney.edu.au.
Julia M HushDiscipline of Physiotherapy, Department of Health Professions, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW, Australia. julia.hush@mq.edu.au.
Mike P JonesPsychology Department, Macquarie University, North Ryde, Sydney, NSW, Australia. mike.jones@mq.edu.au.
Anna MarcuzziDiscipline of Physiotherapy, Department of Health Professions, Faculty of Medicine and Health Sciences, Macquarie University, North Ryde, Sydney, NSW, Australia. anna.marcuzzi@students.mq.edu.au.
Paul J WrigleySydney Medical School Northern, University of Sydney, Sydney, NSW, Australia. paul.wrigley@sydney.edu.au.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIrritable bowel syndrome (IBS) is a common functional gastrointestinal disorder. While abdominal pain is a dominant symptom of IBS, many sufferers also report widespread hypersensitivity and present with other chronic pain conditions. The presence of widespread hypersensitivity and extra-intestinal pain conditions suggests central nervous dysfunction. While central nervous system dysfunction may involve the spinal cord (central sensitisation) and brain, this review will focus on one brain mechanism, descending pain modulation. METHOD/

designWe will conduct a comprehensive search for the articles indexed in the databases Ovid MEDLINE, Ovid Embase, Ovid PsycINFO and Cochrane Central Register of Controlled Trial (CENTRAL) from their inception to August 2015, that report on any aspect of descending pain modulation in irritable bowel syndrome. Two independent reviewers will screen studies for eligibility, assess risk of bias and extract relevant data. Results will be tabulated and, if possible, a meta-analysis will be carried out. DISCUSSION: The systematic review outlined in this protocol aims to summarise current knowledge regarding descending pain modulation in IBS. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42015024284.

Indexed as

AdolescentAdultCentral Nervous SystemHumansIntestinesIrritable Bowel SyndromePainResearch Design

Identifiers

PMID26652749
PMCPMC4674951

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.