ArticleBiodemography and social biology2015
Validation of Biomarkers of CVD Risk from Dried Blood Spots in Community-Based Research: Methodologies and Study-Specific Serum Equivalencies.
Article in Biodemography and social biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Dried Blood Spots to Assess Cardiovascular-Kidney-Metabolic Health.Journal of the American Heart Association · 2025Pooled it
- Employee Cardiometabolic Risk Following a Cluster-Randomized Workplace Intervention From the Work, Family and Health Network, 2009-2013.American journal of public health · 2023Trial
- Study Design and Conceptual Framework of an Observational Study of Food Insecurity and Life's Essential 8 in College Students: The FRESH Study.Journal of the American Heart Association · 2026Observational
- Investigating psychosocial factors and systemic inflammation using dried blood spots: a scoping review.Social psychiatry and psychiatric epidemiology · 2025Article
- Relationship between a Self-Reported History of Depression and Persistent Elevation in C-Reactive Protein after Myocardial Infarction.Journal of clinical medicine · 2022Article
- Non-Lethal Blood Sampling of Fish in the lab and Field With Methods for Dried Blood Plasma Spot Omic Analyses.Frontiers in genetics · 2022Article
- Prevalence of Cardiovascular Disease and Risk Factors Among Somali Immigrants and Refugees.Journal of immigrant and minority health · 2021Article
- The use of dried blood spots for characterizing children's exposure to organic environmental chemicals.Environmental research · 2021Review
- Measurement of mitochondrial DNA copy number in dried blood spots: A pilot study.Mitochondrion · 2021Article
- Discrimination and systemic inflammation: A critical review and synthesis.Brain, behavior, and immunity · 2020Review
- Dried blood spots: Effects of less than optimal collection, shipping time, heat, and humidity.American journal of human biology : the official journal of the Human Biology Council · 2020Article
- Combining lipidomics and machine learning to measure clinical lipids in dried blood spots.Metabolomics : Official journal of the Metabolomic Society · 2020Article
- Measurement of micronutrient deficiency associated biomarkers in dried blood spots using a multiplexed immunoarray.PloS one · 2019Article
- Sleep Health and Predicted Cardiometabolic Risk Scores in Employed Adults From Two Industries.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2018Article
- The Protective Role of Positive Well-Being in Cardiovascular Disease: Review of Current Evidence, Mechanisms, and Clinical Implications.Current cardiology reports · 2016Review
- Blood-borne biomarkers and bioindicators for linking exposure to health effects in environmental health science.Journal of toxicology and environmental health. Part B, Critical reviews · 2016Review
- Work-family conflict, cardiometabolic risk, and sleep duration in nursing employees.Journal of occupational health psychology · 2015Article
- HPLC-based Measurement of Glycated Hemoglobin using Dried Blood Spots Collected under Adverse Field Conditions.Biodemography and social biologyArticle
Corrections and comments
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Authors and funding
9 authors.
Funding
Abstract
Dried blood spot (DBS) methodology offers significant advantages over venipuncture in studies of vulnerable populations or large-scale studies, including reduced participant burden and higher response rates. Uncertainty about the validity of cardiovascular disease (CVD) risk biomarkers remains a barrier to wide-scale use. We determined the validity of DBS-derived biomarkers of CVD risk versus gold-standard assessments, and study-specific, serum-equivalency values for clinical relevance of DBS-derived values. Concurrent venipuncture serum and DBS samples (n = 150 adults) were assayed in Clinical Laboratory Improvement Amendments-certified and DBS laboratories, respectively. Time controls of DBS standard samples were assayed single-blind along with test samples. Linear regression analyses evaluated DBS-to-serum equivalency values; agreement and bias were assessed via Bland-Altman plots. Linear regressions of venipuncture values on DBS-to-serum equivalencies provided R(2) values for total cholesterol, high-density lipoprotein cholesterol (HDL-C), and C-reactive protein (CRP) of 0.484, 0.118, and 0.666, respectively. Bland-Altman plots revealed minimal systematic bias between DBS-to-serum and venipuncture values; precision worsened at higher mean values of CRP. Time controls revealed little degradation or change in analyte values for HDL-C and CRP over 30 weeks. We concluded that DBS-assessed biomarkers represent a valid alternative to venipuncture assessments. Large studies using DBS should include study-specific serum-equivalency determinations to optimize individual-level sensitivity, the viability of detecting intervention effects, and generalizability in community-level primary prevention interventions.
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