Evidence map›Paper›PMID 26652653›Full record

ArticleCell cycle (Georgetown, Tex.)2016

On the influence of protein-DNA register during homologous recombination.

Eric C Greene

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell cycle (Georgetown, Tex.), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Engineering the Drosophila Genome for Developmental Biology.Journal of developmental biology · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Eric C Greenea Department of Biochemistry & Molecular Biophysics , Columbia University , New York , NY , USA.
Columbia University · US

Funding

Protein purification instrumentation in support of single molecule studies of genome integrityR35GM118026 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2016 to 2025
$5.7M
Elucidating the Mechanisms of DNA RecombinationR01GM074739 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2006 to 2015
$2.7M
Visualizing the Dynamics of Chromatin and Chromatin Remodeling ProteinsR01GM082848 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI GREENE, ERIC C · 2008 to 2016
$2.4M
NIGMS NIH HHS GM074739NIGMS NIH HHS GM082848NIGMS NIH HHS R35 GM118026
6 · The paper itself

Abstract

Homologous recombination enables the exchange of genetic information between related DNA molecules and is a driving force in evolution. Using single-molecule optical microscopy we have recently shown that members of the Rad51/RecA family of recombinases stabilize paired homologous strand of DNA in precise 3-nt increments. Here we discuss an interesting conceptual implication of these results, which is that the recombinases may actively sense and reorganize their alignment register relative to the bound DNA sequences to ensure optimal base triplet pairing interactions during the early stages of recombination.

Indexed as

Base PairingBase SequenceBinding SitesDNADNA, Single-StrandedHomologous RecombinationHumansMolecular Sequence DataNucleotidesProtein BindingRad51 RecombinaseSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsDNADNA, Single-StrandedNucleotidesRad51 RecombinaseSaccharomyces cerevisiae Proteins

Identifiers

PMID26652653
PMCPMC4825883
OpenAlexW2278501064

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.