Evidence map›Paper›PMID 26652272›Full record

ArticleParasites & vectors2015

Quantitative analyses and modelling to support achievement of the 2020 goals for nine neglected tropical diseases.

T Déirdre Hollingsworth, Emily R Adams, Roy M Anderson, Katherine Atkins, Sarah Bartsch, María-Gloria Basáñez, Matthew Behrend, David J Blok, Lloyd A C Chapman, Luc Coffeng and 36 more

Open access · goldAbstract read
In one paragraph

Article in Parasites & vectors, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed, 3 pooled it
8.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed, 3 syntheses or guidelines pooled it, 92 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. SCORE Operational Research on Moving toward Interruption of Schistosomiasis Transmission.The American journal of tropical medicine and hygiene · 2020
    Trial
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  8. Article
  9. Article
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  11. Review
  12. Article
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  14. Review
  15. An Ensemble Framework for Projecting the Impact of Lymphatic Filariasis Interventions Across Sub-Saharan Africa at a Fine Spatial Scale.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  16. Subnational Projections of Lymphatic Filariasis Elimination Targets in Ethiopia to Support National Level Policy.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  17. How Does the Proportion of Never Treatment Influence the Success of Mass Drug Administration Programs for the Elimination of Lymphatic Filariasis?Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2024
    Article
  18. Modelling morbidity for neglected tropical diseases: the long and winding road from cumulative exposure to long-term pathology.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  19. Article
  20. Article

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

46 authors at 16 institutions in 5 countries.

T Déirdre HollingsworthUniversity of Warwick, Coventry, CV4 7AL, UK. deirdre.hollingsworth@warwick.ac.uk.
Emily R AdamsLiverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
Roy M AndersonImperial College London, London, W2 1PG, UK.
Katherine AtkinsLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Sarah BartschJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
María-Gloria BasáñezImperial College London, London, W2 1PG, UK.
Matthew BehrendBill and Melinda Gates Foundation, Seattle, USA.
David J BlokErasmus University Medical Center, 3015 CE, Rotterdam, Netherlands.
Lloyd A C ChapmanUniversity of Warwick, Coventry, CV4 7AL, UK.
Luc CoffengErasmus University Medical Center, 3015 CE, Rotterdam, Netherlands.
Orin CourtenayUniversity of Warwick, Coventry, CV4 7AL, UK.
Ron E CrumpUniversity of Warwick, Coventry, CV4 7AL, UK.
Sake J de VlasErasmus University Medical Center, 3015 CE, Rotterdam, Netherlands.
Andy DobsonPrinceton University, New Jersey, NJ, 08544, USA.
Louise DysonUniversity of Warwick, Coventry, CV4 7AL, UK.
Hajnal FarkasUniversity of Warwick, Coventry, CV4 7AL, UK.
Alison P GalvaniYale University, New Haven, CT, 06520, USA.
Manoj GambhirMonash University, Melbourne, VIC, 3800, Australia.
David GurarieCase Western Reserve University, Cleveland, OH, 44106, USA.
Michael A IrvineUniversity of Warwick, Coventry, CV4 7AL, UK.
Sarah JervisUniversity of Warwick, Coventry, CV4 7AL, UK.
Matt J KeelingUniversity of Warwick, Coventry, CV4 7AL, UK.
Louise Kelly-HopeLiverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
Charles KingCase Western Reserve University, Cleveland, OH, 44106, USA.
Bruce Y LeeJohns Hopkins Bloomberg School of Public Health, Baltimore, MD, 21205, USA.
Epke A Le RutteErasmus University Medical Center, 3015 CE, Rotterdam, Netherlands.
Thomas M LietmanUniversity of California, San Francisco, San Francisco, CA, 94143, USA.
Martial Ndeffo-MbahYale University, New Haven, CT, 06520, USA.
Graham F MedleyLondon School of Hygiene and Tropical Medicine, London, WC1E 7HT, UK.
Edwin MichaelUniversity of Notre Dame, South Bend, IN, 47556, USA.
Abhishek PandeyYale University, New Haven, CT, 06520, USA.
Jennifer K PetersonPrinceton University, New Jersey, NJ, 08544, USA.
Amy PinsentMonash University, Melbourne, VIC, 3800, Australia.
Travis C PorcoUniversity of California, San Francisco, San Francisco, CA, 94143, USA.
Jan Hendrik RichardusErasmus University Medical Center, 3015 CE, Rotterdam, Netherlands.
Lisa ReimerLiverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
Kat S RockUniversity of Warwick, Coventry, CV4 7AL, UK.
Brajendra K SinghUniversity of Notre Dame, South Bend, IN, 47556, USA.
Wilma StolkErasmus University Medical Center, 3015 CE, Rotterdam, Netherlands.
Subramanian SwaminathanVector Control Research Centre, Pondicherry, 605006, India.
Steve J TorrLiverpool School of Tropical Medicine, Liverpool, L3 5QA, UK.
Jeffrey TownsendYale University, New Haven, CT, 06520, USA.
James TruscottImperial College London, London, W2 1PG, UK.
Martin WalkerImperial College London, London, W2 1PG, UK.
Alexandra ZouevaChildren's Investment Fund Foundation, London, W1S 2FT, UK.
NTD Modelling Consortium
University of Warwick · GBErasmus MC · NLImperial College London · GBLiverpool School of Tropical Medicine · GBYale University · USCase Western Reserve University · USJohns Hopkins University · USMonash University · AUPrinceton University · USUniversity of California, San Francisco · USUniversity of Notre Dame · USBill & Melinda Gates Foundation · USChildren's Investment Fund Foundation · GBLondon School of Hygiene & Tropical Medicine · GBUniversity of London · GBVector Control Research Centre · IN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Quantitative analysis and mathematical models are useful tools in informing strategies to control or eliminate disease. Currently, there is an urgent need to develop these tools to inform policy to achieve the 2020 goals for neglected tropical diseases (NTDs). In this paper we give an overview of a collection of novel model-based analyses which aim to address key questions on the dynamics of transmission and control of nine NTDs: Chagas disease, visceral leishmaniasis, human African trypanosomiasis, leprosy, soil-transmitted helminths, schistosomiasis, lymphatic filariasis, onchocerciasis and trachoma. Several common themes resonate throughout these analyses, including: the importance of epidemiological setting on the success of interventions; targeting groups who are at highest risk of infection or re-infection; and reaching populations who are not accessing interventions and may act as a reservoir for infection,. The results also highlight the challenge of maintaining elimination 'as a public health problem' when true elimination is not reached. The models elucidate the factors that may be contributing most to persistence of disease and discuss the requirements for eventually achieving true elimination, if that is possible. Overall this collection presents new analyses to inform current control initiatives. These papers form a base from which further development of the models and more rigorous validation against a variety of datasets can help to give more detailed advice. At the moment, the models' predictions are being considered as the world prepares for a final push towards control or elimination of neglected tropical diseases by 2020.

Indexed as

Disease EradicationEpidemiologic MethodsBiostatisticsCommunicable Disease ControlDisease Transmission, InfectiousHumansModels, TheoreticalNeglected Diseases

Identifiers

PMID26652272
PMCPMC4674954
OpenAlexW2190276977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.