ArticleeLife2015
Frequency-selective control of cortical and subcortical networks by central thalamus.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 5 of them syntheses that pooled it.
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Who cites it
104 citing papers in PubMed, 5 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Mental fatigue and brain activation using prolonged task-based fMRI: a systematic review on time-on-task and sequential task paradigms.Experimental brain research · 2026Pooled it
- Thalamus and consciousness: a systematic review on thalamic nuclei associated with consciousness.Frontiers in neurology · 2025Pooled it
- Clinical neuromodulatory effects of deep brain stimulation in disorder of consciousness: A literature review.CNS neuroscience & therapeutics · 2024Pooled it
- Optogenetic fMRI for Brain-Wide Circuit Analysis of Sensory Processing.International journal of molecular sciences · 2022Pooled it
- Structural and functional organization of the midline and intralaminar nuclei of the thalamus.Frontiers in behavioral neuroscience · 2022Pooled it
- Effects of high-definition transcranial direct current stimulation for the treatment of chronic insomnia: a randomized, double-blind, controlled trial.Scientific reports · 2025Trial
- Thalamic deep brain stimulation in traumatic brain injury: a phase 1, randomized feasibility study.Nature medicine · 2023Trial
- Midline thalamic neurons show early hypersynchrony during absence seizures in mouse models.iScience · 2026Article
- Oligodendrocyte prosaposin restores subarachnoid haemorrhage-induced consciousness impairment.Experimental & molecular medicine · 2026Article
- Early microglial response to amyloid plaques drives sleep loss in Alzheimer's disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Improved autobiographical memory with central thalamic deep brain stimulation in traumatic brain injury.Brain communications · 2026Article
- Thalamocortical Structural Covariation Networks Are Related to Familial Risk for Schizophrenia in the Context of Lower Nuclei Volume Estimates in Patients: An ENIGMA Study.Biological psychiatry · 2025Article
- Cortical activity upon awakening from sleep reveals consistent spatio-temporal gradients across sleep stages in human EEG.Current biology : CB · 2025Article
- A human brain network linked to restoration of consciousness after deep brain stimulation.Nature communications · 2025Article
- Elucidating hemodynamics and neuro-glio-vascular signaling using rodent fMRI.Trends in neurosciences · 2025Review
- A novel electroencephalographic evaluation of noxious stimulation during isoflurane anesthesia in dogs.Experimental animals · 2025Article
- Cortical lesions and focal white matter injury are associated with attentional performance in chronic traumatic brain injury.Brain communications · 2025Article
- Proceedings of the 12th annual deep brain stimulation think tank: cutting edge technology meets novel applications.Frontiers in human neuroscience · 2025Article
- Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation.Military Medical Research · 2024Review
- A synergistic workspace for human consciousness revealed by Integrated Information Decomposition.eLife · 2024Article
44 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Central thalamus plays a critical role in forebrain arousal and organized behavior. However, network-level mechanisms that link its activity to brain state remain enigmatic. Here, we combined optogenetics, fMRI, electrophysiology, and video-EEG monitoring to characterize the central thalamus-driven global brain networks responsible for switching brain state. 40 and 100 Hz stimulations of central thalamus caused widespread activation of forebrain, including frontal cortex, sensorimotor cortex, and striatum, and transitioned the brain to a state of arousal in asleep rats. In contrast, 10 Hz stimulation evoked significantly less activation of forebrain, inhibition of sensory cortex, and behavioral arrest. To investigate possible mechanisms underlying the frequency-dependent cortical inhibition, we performed recordings in zona incerta, where 10, but not 40, Hz stimulation evoked spindle-like oscillations. Importantly, suppressing incertal activity during 10 Hz central thalamus stimulation reduced the evoked cortical inhibition. These findings identify key brain-wide dynamics underlying central thalamus arousal regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.