SynthesisCell host & microbe2015
Meta- and Orthogonal Integration of Influenza "OMICs" Data Defines a Role for UBR4 in Virus Budding.
Open access · greenAbstract readMeta-Analysis
In one paragraph
Synthesis in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 579 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
579citing papers in PubMed, 1 pooled it
55.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
579 citing papers in PubMed, 1 synthesis or guideline pooled it, 911 citations in OpenAlex.
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519 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
37 authors at 15 institutions in 3 countries.
Shashank TripathiDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Marie O PohlInstitute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Yingyao ZhouGenomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.
Ariel Rodriguez-FrandsenImmunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Guojun WangDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
David A SteinDepartment of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Hong M MoultonDepartment of Biomedical Sciences, College of Veterinary Medicine, Oregon State University, Corvallis, OR 97331, USA.
Paul DeJesusImmunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Jianwei CheGenomics Institute of the Novartis Research Foundation, 10675 John Jay Hopkins Drive, San Diego, CA 92121, USA.
Lubbertus C F MulderDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Emilio YángüezInstitute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Dario AndenmattenInstitute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland.
Lars PacheImmunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Balaji ManicassamyDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Randy A AlbrechtDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Maria G GonzalezDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Quy NguyenImmunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Abraham BrassMicrobiology and Physiological Systems (MaPS) Department, University of Massachusetts Medical School, Worcester, MA 01605, USA.
Stephen ElledgeDepartment of Genetics, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02127, USA; Howard Hughes Medical Institute, Chevy Chase, MD 20815, USA.
Michael WhiteUniversity of Texas Southwestern Medical Center, 5323 Harry Hines Boulevard, Dallas, TX 75390, USA.
Sagi ShapiraColumbia University, Department of Systems Biology and Department of Microbiology and Immunology, 1130 St. Nicholas Avenue, New York, NY 10032, USA.
Nir HacohenMassachusetts General Hospital, 49 13th Street, Charlestown, MA 02129, USA.
Alexander KarlasMax Planck Institute for Infection Biology, Charitéplatz 1, Campus Charité Mitte, 10117 Berlin, Germany.
Thomas F MeyerMax Planck Institute for Infection Biology, Charitéplatz 1, Campus Charité Mitte, 10117 Berlin, Germany.
Michael ShalesUniversity of California, San Francisco, 1700 4th Street, Byers Hall 309, San Francisco, CA 94158, USA.
Andre GatoranoImmunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Jeffrey R JohnsonUniversity of California, San Francisco, 1700 4th Street, Byers Hall 309, San Francisco, CA 94158, USA.
Gwen JangUniversity of California, San Francisco, 1700 4th Street, Byers Hall 309, San Francisco, CA 94158, USA.
Tasha JohnsonUniversity of California, San Francisco, 1700 4th Street, Byers Hall 309, San Francisco, CA 94158, USA.
Erik VerschuerenUniversity of California, San Francisco, 1700 4th Street, Byers Hall 309, San Francisco, CA 94158, USA.
Doug SandersUniversity of California, San Francisco, 1700 4th Street, Byers Hall 309, San Francisco, CA 94158, USA.
Nevan KroganUniversity of California, San Francisco, 1700 4th Street, Byers Hall 309, San Francisco, CA 94158, USA.
Megan ShawDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Renate KönigImmunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA; Host-Pathogen Interactions, Paul-Ehrlich-Institut, Paul-Ehrlich-Straße 51-59, 63225 Langen, Germany; German Center for Infection Research (DZIF), 63225 Langen, Germany. Electronic address: renate.koenig@pei.de.
Silke StertzInstitute of Medical Virology, University of Zurich, Winterthurerstrasse 190, 8057 Zurich, Switzerland. Electronic address: stertz.silke@virology.uzh.ch.
Adolfo García-SastreDepartment of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA; Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA. Electronic address: adolfo.garcia-sastre@mssm.edu.
Sumit K ChandaImmunity and Pathogenesis Program, Infectious and Inflammatory Disease Center, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: schanda@sbpdiscovery.org.
Icahn School of Medicine at Mount Sinai · USUniversity of California, San Francisco · USDiscovery Institute · USUniversity of Zurich · CHGenomics Institute of the Novartis Research Foundation · USOregon State University · USSanford Burnham Prebys Medical Discovery Institute · USCharité - Universitätsmedizin Berlin · DEColumbia University · USGerman Center for Infection Research · DEHarvard University · USMassachusetts General Hospital · USMax Planck Institute for Infection Biology · DEThe University of Texas Southwestern Medical Center · USUniversity of Massachusetts Chan Medical School · US
Funding
Virology CoreP30AI027763 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STEVEN Grant DEEKS · 1988 to 2026
$93.6MVirus CoreU19AI106754 · NIAID · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI GARCIA-SASTRE, ADOLFO · 2013 to 2017
$26.0MSYNTHETIC SYSTEMSP50GM085764 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI HASTY, JEFF M, IDEKER, TREY · 2010 to 2018
$23.3MQuantitative Studies of influenza EvolutionR01GM109018 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI SHAPIRA, SAGI · 2014 to 2019
$2.6MThe Role of IFITM3 in the Anti-viral Host ResponseR01AI091786 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BRASS, ABRAHAM L · 2011 to 2015
$2.1MTargeting Mechanistic Subtypes of Neoplastic DiseaseR35CA197717 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI WHITE, MICHAEL A. · 2015 to 2015
$725kHoward Hughes Medical InstituteNCI NIH HHS R35 CA197717NIAID NIH HHS 1R01AI091786NIAID NIH HHS P30 AI027763NIAID NIH HHS R01 AI091786NIAID NIH HHS U19 AI106754NIGMS NIH HHS NIH P50 GM085764NIGMS NIH HHS P50 GM085764NIGMS NIH HHS R01 GM109018
Abstract
Several systems-level datasets designed to dissect host-pathogen interactions during influenza A infection have been reported. However, apparent discordance among these data has hampered their full utility toward advancing mechanistic and therapeutic knowledge. To collectively reconcile these datasets, we performed a meta-analysis of data from eight published RNAi screens and integrated these data with three protein interaction datasets, including one generated within the context of this study. Further integration of these data with global virus-host interaction analyses revealed a functionally validated biochemical landscape of the influenza-host interface, which can be queried through a simplified and customizable web portal (http://www.metascape.org/IAV). Follow-up studies revealed that the putative ubiquitin ligase UBR4 associates with the viral M2 protein and promotes apical transport of viral proteins. Taken together, the integrative analysis of influenza OMICs datasets illuminates a viral-host network of high-confidence human proteins that are essential for influenza A virus replication.
Indexed as
Host-Pathogen InteractionsVirus ReleaseAnimalsCalmodulin-Binding ProteinsCell LineComputational BiologyCytoskeletal ProteinsFlow CytometryHumansImmunoprecipitationInfluenza A virusMice, Inbred BALB CMicroscopy, FluorescenceProtein BindingProtein Interaction MapsProtein TransportCalmodulin-Binding ProteinsCytoskeletal ProteinsM2 protein, Influenza A virusUbiquitin-Protein LigasesUBR4 protein, humanViral Matrix ProteinsViroporin Proteins
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