Evidence map›Paper›PMID 26651942›Full record

ArticleCell host & microbe2015

Evolution and Spread of Ebola Virus in Liberia, 2014-2015.

Jason T Ladner, Michael R Wiley, Suzanne Mate, Gytis Dudas, Karla Prieto, Sean Lovett, Elyse R Nagle, Brett Beitzel, Merle L Gilbert, Lawrence Fakoli and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell host & microbe, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.

0numbers the graph read from it
0cells of the map it votes in
64citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

64 citing papers in PubMed.

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  19. Article
  20. Viral genomics in Ebola virus research.Nature reviews. Microbiology · 2020
    Review

4 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jason T LadnerCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA. Electronic address: jason.t.ladner.ctr@mail.mil.
Michael R WileyCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Suzanne MateCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Gytis DudasInstitute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK.
Karla PrietoCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Sean LovettCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Elyse R NagleCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Brett BeitzelCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Merle L GilbertMolecular and Translational Sciences Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Lawrence FakoliLiberian Institute for Biomedical Research, Charlesville, Liberia.
Joseph W DiclaroNaval Medical Research Unit 3, 3A Imtidad Ramses Street, Cairo, Egypt 11517.
Randal J SchoeppDiagnostic Systems Division, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Joseph FairMRI Global, 1330 Piccard Avenue, Rockville, MD, 20850, USA; The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, PA 16802, USA.
Jens H KuhnIntegrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, NIH, B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.
Lisa E HensleyIntegrated Research Facility at Fort Detrick, National Institute of Allergy and Infectious Diseases, NIH, B-8200 Research Plaza, Fort Detrick, Frederick, MD, 21702, USA.
Daniel J ParkBroad Institute, 75 Ames St, Cambridge, MA, 02142, USA.
Pardis C SabetiBroad Institute, 75 Ames St, Cambridge, MA, 02142, USA; Harvard University, 52 Oxford Street, Cambridge, MA, 02138, USA.
Andrew RambautInstitute of Evolutionary Biology, University of Edinburgh, Ashworth Laboratories, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK; Centre for Immunology, Infection and Evolution, University of Edinburgh, Ashworth Laboratories, Charlotte Auerbach Road, Edinburgh EH9 3FL, UK; Fogarty International Center, NIH, 31 Center Drive, Bethesda, MD, 20892, USA.
Mariano Sanchez-LockhartCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Fatorma K BolayLiberian Institute for Biomedical Research, Charlesville, Liberia.
Jeffrey R KugelmanCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA.
Gustavo PalaciosCenter for Genome Sciences, US Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Fort Detrick, Frederick, MD, 21702, USA. Electronic address: gustavo.f.palacios.ctr@mail.mil.

Funding

Intramural NIH HHS Z99 AI999999NIAID NIH HHS HHSN272200700016IWellcome Trust 095831
6 · The paper itself

Abstract

The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

Indexed as

Cluster AnalysisEbolavirusGenetic VariationGenome, ViralGenotypeHemorrhagic Fever, EbolaHumansLiberiaMolecular EpidemiologyMolecular Sequence DataPhylogeographySequence Analysis, DNASequence Homology

Identifiers

PMID26651942
PMCPMC4711363

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.