Evidence map›Paper›PMID 26651463›Full record

ArticleHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2015

Microrandomized trials: An experimental design for developing just-in-time adaptive interventions.

Predrag Klasnja, Eric B Hekler, Saul Shiffman, Audrey Boruvka, Daniel Almirall, Ambuj Tewari, Susan A Murphy

9 registry-linked trialsAbstract read
In one paragraph

Article in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 353 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
353citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03184389 nacompletednot on this mapstarted 2017, after this paper: background citation

Sense2Stop Mobile Sensor Data to Knowledge: Preliminary Study of the Effects of Wearable Sensors and Smartphone Apps on Real Time Stress and Smoking in Recently Quit Smokers

TypeinterventionalSponsorNorthwestern UniversityRan2017 to 2019Enrolled75ConditionsStress, Smoking Cessation, OvereatingArmsPrompt to use smartphone apps for stress management
NCT03225521 nacompletednot on this map

HeartSteps: a Just-in-Time Adaptive Intervention for Increasing Physical Activity Amongst Sedentary Adults.

TypeinterventionalSponsorKaiser PermanenteRan2015 to 2016Enrolled44ConditionsPhysical ActivityArmsHeartSteps: A just-in-time adaptive intervention for increasing physical activity amongst sedentary adults.
NCT03255317 nacompletednot on this mapstarted 2017, after this paper: background citation

Developing a Flexible App Data Collection Tool for Substance Use Research

TypeinterventionalSponsorUniversity of MichiganRan2017 to 2018Enrolled74ConditionsSubstance UseArmsReinforcers, Notifications
NCT03932903 narecruitingnot on this mapstarted 2025, after this paper: background citation

Using Real Time Mobile Health Approaches to Understand and Promote Oral Chemotherapy Adherence in Adolescents and Young Adults With Leukemia

TypeinterventionalSponsorNorthwestern UniversityRan2025 to 2027Enrolled60ConditionsAcute Lymphoblastic Leukemia, Lymphoblastic LymphomaArmsADAPTS (ADherence Assessments and Personalized Timely Support).
NCT03972293 nacompletednot on this mapstarted 2018, after this paper: background citation

2018 Intern Health Study Micro-randomized Trial: Developing a Mobile Health App to Improve Mental Health and Maintain Healthy Behaviors During the Internship Year

TypeinterventionalSponsorUniversity of MichiganRan2018 to 2019Enrolled2,134ConditionsDepression, Mood, Sleep, Physical ActivityArmsIntern Health Study behavioral change mobile notification, Intern Health Study mobile app
NCT05003518 naterminatednot on this mapstarted 2022, after this paper: background citation

ParentText User Engagement and Effectiveness Study

TypeinterventionalSponsorUniversity of OxfordRan2022 to 2022Enrolled1,400ConditionsEngagement, Positive Parenting, Child Maltreatment, Intimate Partner ViolenceArmsParentText
NCT05791643 nacompletednot on this mapstarted 2023, after this paper: background citation

Pilot Micro-Randomized Trial of a Real-Time Intervention for Promoting Safety Plan and Coping Strategy Use for Suicidal Thoughts

TypeinterventionalSponsorMassachusetts General HospitalRan2023 to 2024Enrolled103ConditionsSuicideArmsPersonalized internal and external coping strategies, Personalized internal coping strategies, Personalized external coping strategies, General internal and external coping strategies, General internal coping strategies
NCT05793541 narecruitingnot on this mapstarted 2024, after this paper: background citation

Micro-randomized Trial to Assess Brief, Just-in-time Interventions for Reducing Short-term Suicide Risk

TypeinterventionalSponsorMassachusetts General HospitalRan2024 to 2026Enrolled185ConditionsSuicideArmsPhone call, Text messaging, Automated interactive smartphone-based tool, Non-interactive pop-up messages
NCT07746492 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Digital Real-Time Support for Stress-Induced Smoking and Unhealthy Eating Among Gender and Sexual Minorities in Dhaka

TypeinterventionalSponsorInternational Centre for Diarrhoeal Disease Research, BangladeshRan2026 to 2027Enrolled115ConditionsTobacco Use, Electronic Cigarette Use, Emotional Eating, Stress, PsychologicalArmsJust-in-Time Adaptive Support Message
3 · Its place in the literature

Who cites it

353 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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293 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Predrag KlasnjaSchool of Information, University of Michigan.ORCID 0000-0002-4570-703X
Eric B HeklerSchool of Nutrition and Health Promotion, Arizona State University.
Saul ShiffmanDepartment of Psychology, University of Pittsburgh.
Audrey BoruvkaDepartment of Statistics, University of Michigan.
Daniel AlmirallInstitute of Social Research, University of Michigan.
Ambuj TewariDepartment of Statistics, University of Michigan.
Susan A MurphyDepartment of Statistics, University of Michigan.

Funding

THE REFINEMENT &APPLICATION OF MEDICAL DECISION MAKING IN PREVENTION SCIENCESP50DA010075 · NIDA · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI LANZA, STEPHANIE T · 1996 to 2014
$24.5M
Pilot, Mentoring, and Professional Development CoreP50DA039838 · NIDA · PENNSYLVANIA STATE UNIVERSITY, THE · PI LI, RUNZE · 2015 to 2019
$13.9M
TRAINING U54EB020404 · NIBIB · UNIVERSITY OF MEMPHIS · PI KUMAR, SANTOSH · 2014 to 2018
$11.3M
Novel Methods for Intensive Longitudinal Data in SMART Studies of Drug Abuse and HIVR01DA039901 · NIDA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALMIRALL, DANIEL, NAHUM-SHANI, INBAL BILLIE · 2015 to 2024
$5.4M
Heart Steps: Adaptive mHealth intervention for physical-activity maintenanceR01HL125440 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Predrag Klasnja · 2015 to 2026
$3.8M
Discovering Tailoring Variables in Childhood Mental Health Treatment ResearchR03MH097954 · NIMH · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI ALMIRALL, DANIEL · 2012 to 2013
$166k
NHLBI NIH HHS R01 HL125440NHLBI NIH HHS R01HL12544001NIBIB NIH HHS U54 EB020404NIBIB NIH HHS U54EB020404NIDA NIH HHS P50 DA010075NIDA NIH HHS P50-DA-010075NIDA NIH HHS P50 DA039838NIDA NIH HHS R01 DA039901NIMH NIH HHS R03 MH097954NIMH NIH HHS R03-MH-097954
6 · The paper itself

Abstract

objectiveThis article presents an experimental design, the microrandomized trial, developed to support optimization of just-in-time adaptive interventions (JITAIs). JITAIs are mHealth technologies that aim to deliver the right intervention components at the right times and locations to optimally support individuals' health behaviors. Microrandomized trials offer a way to optimize such interventions by enabling modeling of causal effects and time-varying effect moderation for individual intervention components within a JITAI.

methodThe article describes the microrandomized trial design, enumerates research questions that this experimental design can help answer, and provides an overview of the data analyses that can be used to assess the causal effects of studied intervention components and investigate time-varying moderation of those effects.

resultsMicrorandomized trials enable causal modeling of proximal effects of the randomized intervention components and assessment of time-varying moderation of those effects.

conclusionMicrorandomized trials can help researchers understand whether their interventions are having intended effects, when and for whom they are effective, and what factors moderate the interventions' effects, enabling creation of more effective JITAIs.

Indexed as

Adaptation, PsychologicalHealth BehaviorEarly Medical InterventionHumansRandomized Controlled Trials as TopicResearch DesignTelemedicine

Identifiers

PMID26651463
PMCPMC4732571

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.