Evidence map›Paper›PMID 26651380›Full record

ReviewExpert review of vaccines2016

Routinely vaccinating adolescents against meningococcus: targeting transmission & disease.

Volker Vetter, Roger Baxter, Gülhan Denizer, Marco A P Sáfadi, Sven-Arne Silfverdal, Andrew Vyse, Ray Borrow

Abstract readReview
In one paragraph

Review in Expert review of vaccines, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Carriage prevalence of Neisseria meningitidis in the Americas in the 21st century: a systematic review.The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases
    Pooled it
  3. Review
  4. Article
  5. 2025 update of the Greig Health Record: Part 2-what's controversial?Canadian family physician Medecin de famille canadien · 2026
    Review
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Vaccine Impact and Effectiveness of Meningococcal Serogroup ACWY Conjugate Vaccine Implementation in the Netherlands: A Nationwide Surveillance Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2022
    Article
  16. Article
  17. Review
  18. Article
  19. Evolution of invasive meningococcal disease epidemiology in Europe, 2008 to 2017.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2022
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Volker Vettera GlaxoSmithKline (GSK) Vaccines , Wavre , Belgium.
Roger Baxterb Kaiser Permanente Vaccine Study Center , Oakland , CA , U.S.A.
Gülhan Denizera GlaxoSmithKline (GSK) Vaccines , Wavre , Belgium.
Marco A P Sáfadic Department of Pediatrics , FCM da Santa Casa de Sáo Paulo , Sáo Paulo , Brazil.
Sven-Arne Silfverdald Department of Clinical Sciences, Pediatrics , Umeå University , Umeå , Sweden.
Andrew Vysea GlaxoSmithKline (GSK) Vaccines , Wavre , Belgium.
Ray Borrowe Vaccine Evaluation Unit , Public Health England , Manchester , U.K .

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Adolescents have the highest rates of meningococcal carriage and transmission. Interrupting the adolescent habitat in order to reduce carriage and transmission within adolescents and to other age groups could help to control meningococcal disease at a population level. Compared to immunization strategies restricted to young children, a strategy focused on adolescents may have more profound and long-lasting indirect impacts, and may be more cost effective. Despite challenges in reaching this age-group, experience with other vaccines show that high vaccine coverage of adolescents is attainable.

Indexed as

AdolescentCarrier StateDisease Transmission, InfectiousHumansMeningitis, MeningococcalMeningococcal VaccinesNeisseria meningitidisMeningococcal Vaccinesadolescentcarriagecost-effectivenessepidemiologyherd protectionNeisseria meningitidistransmissionvaccine

Identifiers

PMID26651380
PMCPMC4841019

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.