Trial reportBMC pulmonary medicine2015
The Salford Lung Study protocol: a pragmatic, randomised phase III real-world effectiveness trial in asthma.
Trial report in BMC pulmonary medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01706198 (A 12-month, Open Label, Randomised, Effectiveness Study to Evaluate Fluticasone Furoate), which is not on this map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A 12-month, Open Label, Randomised, Effectiveness Study to Evaluate Fluticasone Furoate (FF, GW685698)/Vilanterol (VI, GW642444) Inhalation Powder Delivered Once Daily Via a Novel Dry Powder Inhaler Compared With Usual Maintenance Therapy in Subjects With Asthma
Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Evaluating the implementation of inclisiran in primary care: process evaluation interim findings from interviews with key stakeholders.BMJ open · 2025Trial
- Trial
- Balanced Crystalloids versus Saline in the Intensive Care Unit. The SALT Randomized Trial.American journal of respiratory and critical care medicine · 2017Trial
- Monitoring safety in a phase III real-world effectiveness trial: use of novel methodology in the Salford Lung Study.Pharmacoepidemiology and drug safety · 2017Trial
- Reporting of Cohort and Routinely Collected Data in Randomised Controlled Trial Protocols (SPIRIT-ROUTINE): extension checklist with explanation and elaboration.BMJ (Clinical research ed.) · 2026Article
- Real-World Comparative Effectiveness Study in Patients with Asthma Initiating Fluticasone Furoate/Vilanterol or Beclometasone Dipropionate/Formoterol Fumarate in General Practice in England.Advances in therapy · 2025Article
- Clinical Trials With Pragmatic Elements: A Review of Use Cases and Real-World Data Utilization.Clinical pharmacology and therapeutics · 2025Review
- Real-world Comparative Effectiveness in Patients with Asthma Newly Initiating Fluticasone Furoate/Vilanterol or Budesonide/Formoterol: A United Kingdom General Practice Cohort Study.Pulmonary therapy · 2025Article
- Design and rationale of the colchicine/statin for the prevention of COVID-19 complications (COLSTAT) trial.Contemporary clinical trials · 2021Article
- Safety data in randomised real-world evidence studies: Salford Lung Study learnings.ERJ open research · 2021Review
- Guidelines for the management of asthma in adults and adolescents: Position statement of the South African Thoracic Society - 2021 update.African journal of thoracic and critical care medicine · 2021Article
- Linkage of primary care prescribing records and pharmacy dispensing Records in the Salford Lung Study: application in asthma.BMC medical research methodology · 2020Article
- Community pharmacy: a crucial enabler in creating the effectiveness study environment in the Salford Lung Studies.The International journal of pharmacy practice · 2020Article
- Article
- Relationship between the Asthma Control Test (ACT) and other outcomes: a targeted literature review.BMC pulmonary medicine · 2020Review
- Real-World Data and Randomised Controlled Trials: The Salford Lung Study.Advances in therapy · 2020Review
- Comparing Randomized Controlled Trials and Real-World Studies in Chronic Obstructive Pulmonary Disease Pharmacotherapy.International journal of chronic obstructive pulmonary disease · 2020Review
- Can medicines development improve outcomes in asthma and chronic obstructive pulmonary disease management by driving effectiveness?Respiratory research · 2019Article
- Using electronic health records for clinical trials: Where do we stand and where can we go?CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne · 2019Article
- Lessons from Outside and Within: Exploring Advancements in Methodology for Naturopathic Medicine Clinical Research.Journal of alternative and complementary medicine (New York, N.Y.) · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundNovel therapies need to be evaluated in normal clinical practice to allow a true representation of the treatment effectiveness in real-world settings. METHODS/
designThe Salford Lung Study is a pragmatic randomised controlled trial in adult asthma, evaluating the clinical effectiveness and safety of once-daily fluticasone furoate (100 μg or 200 μg)/vilanterol 25 μg in a novel dry-powder inhaler, versus existing asthma maintenance therapy. The study was initiated before this investigational treatment was licensed and conducted in real-world clinical practice to consider adherence, co-morbidities, polypharmacy, and real-world factors. PRIMARY ENDPOINT: Asthma Control Test at week 24; safety endpoints include the incidence of serious pneumonias. The study utilises the Salford electronic medical record, which allows near to real-time collection and monitoring of safety data. DISCUSSION: The Salford Lung Study is the world's first pragmatic randomised controlled trial of a pre-licensed medication in asthma. Use of patients' linked electronic health records to collect clinical endpoints offers minimal disruption to patients and investigators, and also ensures patient safety. This highly innovative study will complement standard double-blind randomised controlled trials in order to improve our understanding of the risk/benefit profile of fluticasone furoate/vilanterol in patients with asthma in real-world settings.
trial registrationClinicaltrials.gov, NCT01706198; 04 October 2012.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.