Trial reportPloS one2015
Retinal Arteriolar Morphometry Based on Full Width at Half Maximum Analysis of Spectral-Domain Optical Coherence Tomography Images.
Trial report in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Automated optical coherence tomography quantification of retinal wall-to-lumen alterations in preeclampsia.Hypertension research : official journal of the Japanese Society of Hypertension · 2026Article
- Ophthalmological Microvascular Changes in ANOCA/INOCA Disease and Ophthalmological Methods to Detect Them-A Systematic Review.Journal of clinical medicine · 2026Review
- TransDualSegNet: transformer dual segment network for retinal vasculature segmentation in OCT.Quantitative imaging in medicine and surgery · 2025Article
- Exploring the effect of gestational diabetes mellitus on retinal vascular morphology by PKSEA-Net.Frontiers in cell and developmental biology · 2024Article
- Application of the full-width-at-half-maximum image segmentation method to analyse retinal vascular changes in patients with internal carotid artery stenosis.Frontiers in cell and developmental biology · 2024Article
- A semantic segmentation method to analyze retinal vascular parameters of diabetic nephropathy.Frontiers in medicine · 2024Article
- Retinal Vascular Geometry in Hypertension: cSLO-Based Method.Ophthalmology and therapy · 2023Article
- Analysis of retinal arteriolar and venular parameters in primary open angle glaucoma.International journal of ophthalmology · 2023Article
- Application of the Full-Width-at-Half-Maximum Image Segmentation Method to Analyse Retinal Vascular Changes in Patients with Diabetic Retinopathy.Journal of healthcare engineering · 2022Review
- Correlations between Retinal Arterial Morphometric Parameters and Neurodegeneration in Patients with Type 2 Diabetes Mellitus with No or Mild Diabetic Retinopathy.Medicina (Kaunas, Lithuania) · 2021Article
- A full-width half-maximum method to assess retinal vascular structural changes in patients with ischemic heart disease and microvascular anginga.Scientific reports · 2019Article
- Comparative Study of Optical Coherence Tomography Angiography and Phase-Resolved Doppler Optical Coherence Tomography for Measurement of Retinal Blood Vessels Caliber.Translational vision science & technology · 2018Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesIn this study, we develop a microdensitometry method using full width at half maximum (FWHM) analysis of the retinal vascular structure in a spectral-domain optical coherence tomography (SD-OCT) image and present the application of this method in the morphometry of arteriolar changes during hypertension.
methodsTwo raters using manual and FWHM methods measured retinal vessel outer and lumen diameters in SD-OCT images. Inter-rater reproducibility was measured using coefficients of variation (CV), intraclass correlation coefficient and a Bland-Altman plot. OCT images from forty-three eyes of 43 hypertensive patients and 40 eyes of 40 controls were analyzed using an FWHM approach; wall thickness, wall cross-sectional area (WCSA) and wall to lumen ratio (WLR) were subsequently calculated.
resultsMean difference in inter-rater agreement ranged from -2.713 to 2.658 μm when using a manual method, and ranged from -0.008 to 0.131 μm when using a FWHM approach. The inter-rater CVs were significantly less for the FWHM approach versus the manual method (P < 0.05). Compared with controls, the wall thickness, WCSA and WLR of retinal arterioles were increased in the hypertensive patients, particular in diabetic hypertensive patients.
conclusionsThe microdensitometry method using a FWHM algorithm markedly improved inter-rater reproducibility of arteriolar morphometric analysis, and SD-OCT may represent a promising noninvasive method for in vivo arteriolar morphometry.
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