ReviewEuropean journal of trauma and emergency surgery : official publication of the European Trauma Society2016
Protocols for massive blood transfusion: when and why, and potential complications.
Review in European journal of trauma and emergency surgery : official publication of the European Trauma Society, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed.
- Article
- Prehospital blood for the injured in conflict zones: what about civilians? - a scoping review.Conflict and health · 2025Review
- Analysis of Massive Transfusion Protocol Utilization in Trauma Across Sociodemographic Groups.Medicina (Kaunas, Lithuania) · 2025Article
- [Typical causes and clinical presentations of traumatic and nontraumatic soft tissue and organ haemorrhage in emergency departments].Radiologie (Heidelberg, Germany) · 2025Review
- Blood Transfusion for Major Trauma in Emergency Department.Diagnostics (Basel, Switzerland) · 2024Review
- The Association of Acetabulum Fracture and Mechanism of Injury with BMI, Days Spent in Hospital, Blood Loss, and Surgery Time: A Retrospective Analysis of 67 Patients.Medicina (Kaunas, Lithuania) · 2024Article
- Intraosseous access in the resuscitation of patients with trauma: the good, the bad, the future.Trauma surgery & acute care open · 2024Review
- Peripartum Haemorrhage: Haemostatic Aspects of the Updated Peripartum Haemorrhage Guideline of the German-Speaking Countries.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2023Review
- Complications and related risk factors of transradial access cannulation for hemodynamic monitoring in general surgery: a prospective observational study.BMC anesthesiology · 2023Observational
- The efficacy and safety of tranexamic acid in rheumatoid arthritis patients undergoing simultaneous bilateral total knee arthroplasty: a multicenter retrospective study.BMC musculoskeletal disorders · 2023Article
- Using multiple indicators to predict the risk of surgical site infection after ORIF of tibia fractures: a machine learning based study.Frontiers in cellular and infection microbiology · 2023Article
- Management of Hemorrhagic Shock: Physiology Approach, Timing and Strategies.Journal of clinical medicine · 2022Review
- Article
- A Cohort Study in Intensive Care Units: Health Decisions Related to Blood Transfusion during the COVID-19 Pandemic.Journal of clinical medicine · 2022Article
- Epidemiology and Associated Factors in Transfusion Management in Intensive Care Unit.Journal of clinical medicine · 2022Article
- Blood Transfusion Reactions-A Comprehensive Review of the Literature including a Swiss Perspective.Journal of clinical medicine · 2022Review
- Emergency Blood Transfusion for Trauma and Perioperative Resuscitation: Standard of Care.Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie · 2021Review
- Surgical Site Infection Following Intramedullary Nailing of Subtrochanteric Femoral Fractures.Journal of clinical medicine · 2021Article
- Comparing hemostatic resuscitation management of intraoperative massive bleeding with traumatic massive bleeding: a computer simulation.Anesthesia and pain medicine · 2020Article
- Pre-hospital transfusion of red blood cells. Part 1: A scoping review of current practice and transfusion triggers.Transfusion medicine (Oxford, England) · 2020Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeAn update paper on massive bleeding after major trauma. A review of protocols to address massive bleeding, and its possible complications, including coagulation abnormalities, complications related to blood storage, immunosuppression and infection, lung injury associated with transfusion, and hypothermia is carried out.
methodsLiterature review and discussion with authors' experience.
resultsMassive bleeding is an acute life-threatening complication of major trauma, and consequently its prompt diagnosis and treatment is of overwhelming importance. Treatment requires rapid surgical management together with the massive infusion of colloid and blood.
conclusionsSince massive transfusion provokes further problems in patients who are already severely traumatized and anaemic, once this course of action has been decided upon, a profound knowledge of its potential complications, careful monitoring and proper follow-up are all essential. To diagnose this bleeding, most authors favour, as the main first choice tool, a full-body CT scan (head to pelvis), in non-critical severe trauma cases. In addition, focused abdominal sonography for trauma (FAST, an acronym that highlights the necessity of rapid performance) is a very important diagnostic test for abdominal and thoracic bleeding. Furthermore, urgent surgical intervention should be undertaken for patients with significant free intraabdominal fluid and haemodynamic instability. Although the clinical situation and the blood haemoglobin concentration are the key factors considered in this rapid decision-making context, laboratory markers should not be based on a single haematocrit value, as its sensitivity to significant bleeding may be very low. Serum lactate and base deficit are very sensitive markers for detecting and monitoring the extent of bleeding and shock, in conjunction with repeated combined measurements of prothrombin time, activated partial thromboplastin time, fibrinogen and platelets.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.