Evidence map›Paper›PMID 26650688›Full record

ArticleEuropean archives of psychiatry and clinical neuroscience2017

Variation at NRG1 genotype related to modulation of small-world properties of the functional cortical network.

Alba Lubeiro, Javier Gomez-Pilar, Oscar Martín, Aitor Palomino, Myriam Fernández, Ana González-Pinto, Jesús Poza, Roberto Hornero, Vicente Molina

Abstract read
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In one paragraph

Article in European archives of psychiatry and clinical neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alba LubeiroPsychiatry Department, Faculty of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain.
Javier Gomez-PilarBiomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Paseo de Belén, 15, 47011, Valladolid, Spain.
Oscar MartínPsychiatry Department, Faculty of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain.
Aitor PalominoNeurotek, Neurosciences Department, Achucarro Basque Center for Neurosciences, University of the Basque Country, 48170, Zamudio, Vizcaya, Spain.
Myriam FernándezPsychiatry Department, Hospital Universitario de Álava, Jose Atxotegi, s/n, 01009, Vitoria-Gasteiz, Álava, Spain.
Ana González-PintoPsychiatry Department, Hospital Universitario de Álava, Jose Atxotegi, s/n, 01009, Vitoria-Gasteiz, Álava, Spain.
Jesús PozaBiomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Paseo de Belén, 15, 47011, Valladolid, Spain.
Roberto HorneroBiomedical Engineering Group, E.T.S. Ingenieros de Telecomunicación, University of Valladolid, Paseo de Belén, 15, 47011, Valladolid, Spain.
Vicente MolinaPsychiatry Department, Faculty of Medicine, University of Valladolid, Av. Ramón y Cajal, 7, 47005, Valladolid, Spain. vicente.molina@uva.es.
Universidad de Valladolid · ESHospital Universitario Araba · ESAchucarro Basque Center for Neuroscience · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Functional brain networks possess significant small-world (SW) properties. Genetic variation relevant to both inhibitory and excitatory transmission may contribute to modulate these properties. In healthy controls, genotypic variation in Neuregulin 1 (NRG1) related to the risk of psychosis (risk alleles) would contribute to functional SW modulation of the cortical network. Electroencephalographic activity during an odd-ball task was recorded in 144 healthy controls. Then, small-worldness (SWn) was calculated in five frequency bands (i.e., theta, alpha, beta1, beta2 and gamma) for baseline (from -300 to the stimulus onset) and response (150-450 ms post-target stimulus) windows. The SWn modulation was defined as the difference in SWn between both windows. Association between SWn modulation and carrying the risk allele for three single nucleotide polymorphisms (SNP) of NRG1 (i.e., rs6468119, rs6994992 and rs7005606) was assessed. A significant association between three SNPs of NRG1 and the SWn modulation was found, specifically: NRG1 rs6468119 in alpha and beta1 bands; NRG1 rs6994992 in theta band; and NRG1 rs7005606 in theta and beta1 bands. Genetic variation at NRG1 may influence functional brain connectivity through the modulation of SWn properties of the cortical network.

Indexed as

AdolescentAdultAllelesAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedBrain MappingBrain WavesCerebral CortexElectroencephalographyFemaleGenetic TestingHumansMaleNerve NetNeuregulin-1Neuropsychological TestsAntibodies, MonoclonalAntibodies, Monoclonal, HumanizedbriakinumabNeuregulin-1NRG1 protein, humanImaging geneticsNeuroimagingNRG1PsychosisSmall-world

Identifiers

PMID26650688
OpenAlexW2237299257

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.